HPV对生殖系统影响的研究进展

人乳头瘤病毒（HPV）感染可引发生殖系统的疣变以及恶性肿瘤.其中高危型HPV的感染导致了约70%的女性宫颈癌.HPV病毒蛋白可通过调节细胞基因组的稳定性、转录活性、泛素化途径和细胞代谢等机制诱发癌症.同时HPV的持续慢性感染和免疫应答的紊乱也与宫颈癌的发生相关.本文对HPV感染对生殖系统健康的影响、HPV病毒分子结构、HPV病毒蛋白的致癌的机制以及宿主对于HPV感染的免疫应答的近期研究进展进行了综述,并总结展望了HPV相关生殖系统疾病的预防和治疗的前景.

Research progress in HPV effect on reproductive system

Infection of Human PapiUomaviruses （HPV） is associated with genital warts and malignant tumor of reproductive system. High - risk types of HPV infection causes about 70% of cervical cancer. The HPV viral protein can induce carcinogenic progression through altering the genomic stability, the transcription factor activity, the ubiquifinafion path-way and the cellular metabolism of host cells. Moreover, persistent HPV infection and deregulation of host immune response are also related to the incidence of cervical cancer. The paper reviews the effects of HPV infection on reproductive system, HPV viral protein structure, the oncogenic mechanisms of HPV viral proteins and the host immune response to HPV infection. It also discusses the prevention and potential therapeutic options for HPV- related diseases in productive system.