红细胞沉降率与C反应蛋白升高对类风湿性关节炎合并2型糖尿病患者血糖血脂代谢的影响

目的探讨红细胞沉降率(ESR)、C反应蛋白(CRP)升高对类风湿性关节炎(RA)合并2型糖尿病(T2DM)患者血糖血脂水平的影响。方法选择62例RA合并T2DM患者作为研究对象,检测血清三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)、餐后2 h血糖(PBG)、CRP、糖化血清白蛋白(GA)、糖化血红蛋白(HbA1c)和ESR。按照ESR是否升高将62例患者分为2组,比较各指标的差异;按CRP是否升高将62例患者分为2组,比较各指标的差异。结果 ESR升高组患者TC/HDL-C高于ESR正常组,差异有统计学意义(P<0.05),GA及CRP水平显著高于ESR正常组,差异有统计学意义(P<0.01);CRP升高组患者HbA1c、GA水平高于CRP正常组,差异有统计学意义(P<0.05),ESR水平显著高于CRP正常组,差异有统计学意义(P<0.01)。结论 RA合并T2DM患者高水平炎症状态可引起血糖血脂代谢紊乱,可能导致其患心血管疾病风险增加。

Effect of elevated erythrocyte sedimentation rate and C-reactive protein on blood glucose and blood lipid metabolism of patients with rheumatoid arthritis combined with type 2 diabetes mellitus

Objective To explore the effect of elevated erythrocyte sedimentation rate （ESR） and C-reactive protein （CRP） on blood glucose and blood lipid metabolism of patients with rheumatoid arthritis（ RA ）combined with type 2 diabetes mellitus（T2DM）. Methods Sixty-two patients of RA combined with T2DM as research subjects. The serum triglyceride （ TG）, total cholesterol （ TC ）, high density lipoprotein cholesterol （ HDL-C ）, low-density lipoprotein cholesterol （ LDL-C ）, fasting blood glucose （ FBG ）, 2 b postprandial blood glucose （ PBG ）, CRP, glyeated albumin （ GA ）, glycosylatcd hemoglobin （HbAIe） and ESR were detected. Sixty-two patients were divided into two groups according to levels of ESR and CRP respectively. Each index was compared in each groups. Results The TC/HDL-C, GA and CRP in elevated ESR group were significantly higher than those in normal ESR group（P 〈 0.05,P 〈 0.01 ） ;the HbA1 c, GA and ESR levels in elevated CRP group were significantly higher than those in normal CRP group （ P 〈 0.05, P 〈 0.01 ）. Conclusion High levels of inflammatory state in patients of RA combined with T2DM may lead to blood glucose and lipids metabolism disorders, then may increase the risk of cardiovascular disease.