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| 乌三颗粒对肿瘤新生血管形成的干预作用及机制研究 | |
| 引用本文： | 石锦萍,杨红,周毅,董丹丹,李科,藏志和,辛志伟,高丽元,沈映君,黄秀凤.乌三颗粒对肿瘤新生血管形成的干预作用及机制研究[J].中药药理与临床,2003,19(1):22-24. |
| 作者姓名： | 石锦萍 杨红 周毅 董丹丹 李科 藏志和 辛志伟 高丽元 沈映君 黄秀凤 |
| 作者单位： | 1. 第三军医大学成都军医学院人体结构教研室,成都,610083 2. 四川省人民医院病理科 3. 成都中医药大学 |
| 基金项目： | 重庆科委立题课题 (1 999)，四川省教委青年基金重点课题 (2 0 0 0 A71 ) |
| 摘 要： | 目的：探讨乌三颗粒对肿瘤新生血管形成的干预及干预机制。方法：采用免疫组织化学染色法，病理彩色图像定量分析法，对各小鼠S180肉瘤组织进行MVD、VEGF和bFGF表达的检测，结果：乌三颗粒能明显下调MVD、VEGF和bFGF的表达。结论：乌三颗粒对肿瘤新生血管的形成有明显干预作用，这可能是乌三颗粒抗肿瘤的重要途径之一。 |
| 关 键 词： | 乌三颗粒 干预作用 S180肉瘤 新生血管形成 中药 药理 |
Inhibitory effect and mechanism of Wusan Granule (乌三颗粒) on tumor angiogensis |
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| Shi Jinping,yang Hong,Zhou Yi,et al..Inhibitory effect and mechanism of Wusan Granule (乌三颗粒) on tumor angiogensis[J].Pharmacology and Clinics of Chinese Materia Medica,2003,19(1):22-24. | |
| Authors: | Shi Jinping yang Hong Zhou Yi |
| Abstract: | Objective: To study inhibitory effect and mechanism of Wusan Granule on tumor angiogensis. Methods: The expression of MVD?VEGF and bFGF in S 180 sarcoma were studied by using immunohistochemistry, and were assessed by computer image analysis system. Results: The expression of MVD?VEGF and bFGF were decreased significantly by treatment of Wusan Granule, compared with the control group. Conclusion: Wusan Granule can obviously inhibit the tumor angiogensis and it is the one of pathways on anti tumor of Wusan Granule. |
| Keywords: | Wusan Granule S 180 sarcoma angiogensis |
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