健脾益肾方治疗慢性肾衰竭62例临床观察

目的:观察中药健脾益肾方与氯沙坦联用对慢性肾衰竭患者蛋白尿、肾功能、血浆白蛋白、血红蛋白的影响.方法:将患者随机分为两组.治疗组给予健脾益肾方每日1剂,氯沙坦100 mg,每日1次;对照组仅予氯沙坦100 mg,每日1次,疗程12周,治疗前后检查慢性肾衰竭患者24 h尿蛋白定量、肾功能、血浆白蛋白、血红蛋白.结果:健脾益肾方与氯沙坦联用能更显著地降低蛋白尿及血清肌酐、尿素氮水平,明显升高血浆白蛋白及血红蛋白水平(P<0.05或P<0.01).结论:健脾益肾方与氯沙坦联用对慢性肾衰竭患者有较好的治疗作用.

The Clinical Study of the Jianpiyishenfang in Treating Chronic Renal Failure

Objective:To observe the influence of the Jianpiyishenfang combining with Losartan in treating chronic renal failure in term of 24 h-urine protein excretion, serum creatinine(Scr), blood urea nitrogen(BUN), albumin(Alb) and hemoglobin.Methods:All patients of CRF were randomly divided into two groups:"treatment group"and "control group".The treatment group received Jianpiyishenfang combined with Losartan and the control group received Losartan.24 h-urine protein excretion,serum creatinine(Scr), blood urea nitrogen(BUN),albumin(Alb) and hemoglobin were measured before and 12 weeks after treatment.Results:24 h-urine protein excretion, serum creatinine(Scr), blood urea nitrogen(BUN) were significantly decreased after treatment while albumin(Alb) and hemoglobin significantly increased(P<0.05).Conclusion:Combination Jianpiyishenfang with Losartan have synergistic effects in treating CRF.