白介素-1和白介素-6与癫痫及其认知功能障碍的关系

癫痫作为一种严重危害人类健康的常见病，省30％-40％癫痫患者存在不同程度的认知障碍。近年来，对癫痫患者认知功能改变的研究与干预工作受到广泛重视，但其机制仍不清楚。研究证实白介素-1（IL-1）和白介素-6（IL-6）参与认知功能。癫痫发作后引起脑组织和血液IL-1和IL-6水平升高，可能与癫痫后认知功能损害有关。本文就IL-1和IL-6与癫痫及其认知功能障碍的关系进行综述。

Interleukin-1 and Interleuldn-6 in Cognitive Impairment with Epilepsy

Epilepsy is a common disease. 30%--40% of the patients with epilepsy have cognitive impairment. In recently years, more and more attentions are paid to the study and intervention of the cognitive function with epilepsy, but the exact mechanisms of epilepsy-related cognitive dysfunction are not clear, It is well documented that IL-1 and IL-6 participate in cognitive function. The levels of IL-1 and IL-6 are increased after seizures in the nervous tissue and serum, which may lead to epilepsy-related cognitive dysfunction. The relationship between IL-1, IL-6 and cognitive impairment with epilepsy were discussed.