气管移植的研究进展

气管移植目前仍处于动物实验阶段,影响气管移植应用主要因素在于移植气管的再血管化、有效的免疫抑制及供者气管的保存、带蒂大网膜包裹移植 管是移植体再血管化的有效方法。先期将气管移植体置于大网膜内,再将带蒂大网膜气管移植能明显提高移植体的再血管化,并降低移植体的感染率,气管的再血管化仍受到气管移植长度的限制,为解决这一问题,近年利用分段气管移植能有效延长气管移植开度,动物实验表明,气楠样存在移植排斥反应

Research Progress on Tracheal Transplantation

Tracheal transplantation is still in the period of animal experiment. The principal factors which prevent tracheal transplantation applied clinically are revascularization of grafts, immunosuppression and long term preservation of grafts. Omentopexy is an effective method for revascularization of tracheal graft. The tracheal allog raft is embeded in the ometum, then the second stage tracheal transplantation approach with pedicled omentum can increase the rate of successful revascularization, and reduce the rate of infection of grafts. There is a limit to the length of tracheal transplantation with revascularization. To solve the problem, split transplantation of trachea is being used, and this method can extend the length of tracheal transplantation. Results of animal experiment showed that there was still graft rejection after tracheal transplantation. Using immunosuppressant can obviously reduce graft rejection, but it increased the infection rate of grafts. Using large dose of immunosuppressant early can inhibit graft rejection after tracheal transplantation and can reduce rate of infection. The tracheal structure is simple, and long term preservation of grafts is possible. Long term cryopreservation of tracheal grafts, which are preserved in Euro Collin solution, is reliable. This simple method can solve both donor shortage and immunosuppression problems.