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IL-9和IL-1O基因拷贝数与银屑病发病的相关性
引用本文:胡小平,陈办成,邵勇,张杰,唐莉华,于波. IL-9和IL-1O基因拷贝数与银屑病发病的相关性[J]. 中国麻风皮肤病杂志, 2014, 0(1): 14-16
作者姓名:胡小平  陈办成  邵勇  张杰  唐莉华  于波
作者单位:北京大学深圳医院皮肤科,广东深圳518036
基金项目:广东省自然科学基金项目(编号:s2012040006694)广东省医学科研基金项目(编号:B2012329)深圳市科技计划项目(编号:201203035)
摘    要:
目的:确定白介素-9(IL-9)和白介素-10(IL-10)基因拷贝数与银屑病发病的相关性。方法:采用RT-PCR对424例银屑病患者和424名健康者的IL-9和IL-10基因拷贝数变异进行检测和比较。结果:银屑病患者的IL-9和IL-10基因拷贝数较健康人基因拷贝数显著增高(P〈0.05)。结论:IL-9和IL-10基因拷贝数增加可能会增加对银屑病的易感性。

关 键 词:白介素-9  白介素-10  基因拷贝数  银屑病

Relationship of IL-9 and IL-10 gene copy number variations with psoriasis
Affiliation:HU Xiao-ping , CHEN Ban-cheng , SHAO Yong , et al. Department of Dermatology, Shenzhen Hospital, Beijing University, Shenzhen , 518036
Abstract:
Objective: To determine the association of interleukin-9 (IL-9) and interleukin- 10 ( IL- 10) gene copy number variations with psoriasis. Methods: Determination of gene copy number of IL-9 and IL-10 was achieved by RT-PCR method and compared between 424 psoriatic patients and 424 healthy controls. Re suits: The IL-9 and IL-10 gene copy number was higher in the psoriatic patients than in the healthy controls (P〈0.05). Conclusion: The increasing of IL-9 and IL-10 gene copy numbers may increase the susceptibili ty to psoriasis.
Keywords:interleukin-9  interleukin-10  gene copy number  psoriasis
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