低分子肝素治疗急性脑梗死的临床研究

目的观察低分子肝素(LMWH)治疗急性脑梗死的临床疗效。方法将70例急性脑梗死患者随机分为对照组(常规治疗)和治疗组(LMWH+常规治疗),分别予治疗前和治疗后7、14、21d行神经功能缺损评分及疗效判定,检测治疗前后凝血指标。结果治疗组总有效率(91.7%)明显优于对照组(67.7%),神经功能缺损评分改善显著(P<0.05),且能延长部分凝血活酶时间(APTT)。结论低分子肝素治疗急性脑梗死疗效显著,有助于神经功能改善,方法简便,安全。

Clinical study on low molecular weight heparin for treatment of acute cerebral infarction

Objective To observe the effect of low molecular weight heparin(LMWH)in treatment of acute cerebral infarction.Methods Seventy cases with acute cerebral infarction,were randomly divided into two groups.One group was given routine drug treatment and another was given LMWH treatment at the same time.The neurological defect scoring system was used to evaluate the patients responses to LMWH.The blood coagulation and fibrillolytic system were examined before and after treatment.Results Effective rate was significantly highter in the LMWH treated group than in the control group.The neurological defect score was significantly improved(P<0.05).Active partial thromboplastin time(APTT)was prolonged(P<0.05).Conclusion These findings suggest that LMWH has a definite therapeutic efficacy for acute cerebral infarction and it can promote neurologic defect score.It is a safe and simple therapeutic method.