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| 人喉部肿瘤PCNA表达及AgNORs计数的研究 | |
| 引用本文： | 许平,许伟,魏永昆,张云汉. 人喉部肿瘤PCNA表达及AgNORs计数的研究[J]. 郑州大学学报(医学版), 1998, 0(3) |
| 作者姓名： | 许平 许伟 魏永昆 张云汉 |
| 作者单位： | 河南医科大学第一附属医院病理科，河南省肿瘤病理学重点实验室，周口纺织医院耳鼻咽喉科 |
| 摘 要： | 采用免疫组化染色及银染技术，对５５例喉部病变中ＰＣＮＡ表达及ＡｇＮＯＲｓ计数进行了检测。结果显示：慢性喉炎、喉乳头状瘤及喉癌的ＰＣＮＡ指数分别为１５０１％、２６３８％和４８０６％，组间两两比较有显著差异（Ｐ＜０００１）。ＡｇＮＯＲｓ计数分别为２６２，３３４和４８８，组间两两比较有明显差异（Ｐ＜００１）。高、中、低分化鳞癌的ＰＣＮＡ指数组间两两比较有显著差异（Ｐ＜０００１）；ＰＣＮＡ指数与ＡｇＮＯＲｓ计数间未见相关性。结果提示：ＰＣＮＡ表达与ＡｇＮＯＲｓ计数在喉不同病变间存在明显差异，对此两项指标的检测有助于了解喉良、恶性肿瘤的细胞增殖状态，在喉良、恶性肿瘤鉴别及恶性分级上有一定价值 |
| 关 键 词： | 喉肿瘤；乳头状瘤；增殖细胞核抗原；核仁组成区 |
Expression of PCNA and AgNORs count in human laryngeal tumor |
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| Xu Ping ),Xu Wei ),Wei Yongkun ),Zhang Yunhan ) ). Expression of PCNA and AgNORs count in human laryngeal tumor[J]. Journal of Zhengzhou University: Med Sci, 1998, 0(3) | |
| Authors: | Xu Ping ) Xu Wei ) Wei Yongkun ) Zhang Yunhan ) ) |
| Affiliation: | Xu Ping 1),Xu Wei 2),Wei Yongkun 1),Zhang Yunhan 1) 1)Department of Pathology,the First Affiliated Hospital,Henan Medical University,Henan Key Laboratory of Tumor Pathology,Zhengzhou*"450052 2)Division of Otolarng |
| Abstract: | By using immunohistochemical staining and silver staining techniques,55 cases of laryngeal lesion were examined for PCNA expression and AgNORs count.The results revealed that the PCNA indices in chronic laryngitis,laryngeal papilloma and laryngeal carcinoma were 15.01%,26.38% and 48.06%,respectively.There were significant differences between two of them ( P <0.001).The AgNORs counts in chronic laryngitis,laryngeal papilloma and laryngeal carcinoma were 2.62,3.34 and 4.88,respectively. Significant differences were found between two of them ( P <0.01).The PCNA indices were significantly different between two group of high,moderately and poorly differentiated squamous cell carcinoma ( P < 0.01) .No statistical correlation was found between PCNA index and AgNORs count.The findings indicate that the expression of PCNA and AgNORs count are significantly different in different kinds of laryngeal lesions suggesting that the detection of these cell proliferation markers may be helpful in the understanding of cell proliferation status of benign and malignant laryngeal tumors and might be valuable in the distinguishing of benign and malignant tumor and in the evaluation of malignant grade of laryngeal carcinoma |
| Keywords: | laryngeal neoplasms papilloma proliferating cell nuclear antigen AgNORs |
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