| 慢性乙型肝炎患者HBV特异性CTL、非特异性CTL的变化和意义 |
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| 引用本文： | 顾锡炳,杨小娟,王栋,吴杭源,徐月琴,陆忠华. 慢性乙型肝炎患者HBV特异性CTL、非特异性CTL的变化和意义[J]. 免疫学杂志, 2010, 26(5) |
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| 作者姓名： | 顾锡炳 杨小娟 王栋 吴杭源 徐月琴 陆忠华 |
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| 作者单位： | 无锡市传染病医院肝病科,214005;无锡市传染病医院肝病科,214005;无锡市传染病医院肝病科,214005;无锡市传染病医院肝病科,214005;无锡市传染病医院肝病科,214005;无锡市传染病医院肝病科,214005 |
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| 摘 要： | 目的探讨慢性乙型肝炎(CHB)患者的外周血HBV特异性CTL、非特异性CTL的变化和意义。方法对80例人白细胞抗原(HLA)-A2阳性的CHB患者用流式细胞仪检测外周血HBV特异性CTL、非特异性CTL和T细胞亚群,对20例HLA-A2阳性的急性乙型肝炎(AHB)患者作HBV特异性CTL、非特异性CTL的检测,30例健康献血员作非特异性CTL和T细胞亚群的检测作为对照。结果80例CHB患者的HBV特异性CTL低于急性乙型肝炎患者,分别为(0.32±0.11)%和(1.1±0.31)%,t=7.704,P=0.000,非特异性CTL高于正常对照组,分别为(18.23±5.13)%和(15.83±4.99%),t=2.220,P=0.028。结论CHB患者的HBV特异性CTL较低,一方面是导致HBV慢性持续感染的主要原因,另一方面启动了非特异性CTL引起肝功能损害。
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| 关 键 词： | 慢性乙型肝炎 乙型肝炎病毒 细胞毒性T细胞 |
Changes of HBV specific and nonspecific cytotoxic T lymphocytes in patients with chronic hepatitis B and its significance |
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| GU Xibing,YANG Xiaojuan,WANG Dong,WU Hangyuan,XU Yueqin,LU Zhonghua. Changes of HBV specific and nonspecific cytotoxic T lymphocytes in patients with chronic hepatitis B and its significance[J]. Immunological Journal, 2010, 26(5) |
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| Authors: | GU Xibing YANG Xiaojuan WANG Dong WU Hangyuan XU Yueqin LU Zhonghua |
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| Affiliation: | GU Xibing,YANG Xiaojuan,WANG Dong,WU Hangyuan,XU Yueqin,LU Zhonghua Department of Liver Diseases,Wuxi Hospital for Infectious Disease,Wuxi 214005,China |
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| Abstract: | We aimed to investigate the changes and significance of peripheral blood HBV specific and nonspecific cytotoxic T lymphocytes(CTL) in patients with chronic hepatitis B(CHB).By using flow cytometry,we examined peripheral blood HBV specific/ nonspecific CTL and T cell subgroups in 80 CHB patients with positive human leukocyte antigen(HLA)-A2,HBV specific CTL and nonspecific CTL in 20 patients with acute hepatitis B(AHB) with positive HLA-A2,as well as nonspecific CTL and T cell subgroups in 30 healthy blood d... |
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| Keywords: | Chronic hepatitis B Hepatitis B virus Cytotoxic T lymphocytes |
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