注射用硝普钠在氯化钠注射液中稳定性研究

目的考察注射用硝普钠与氯化钠注射液配伍的稳定性。方法将注射用硝普钠，根据临床应用需要配制成溶液，考察在不同环境下，不同放置时间硝普钠溶液的稳定性，包括溶液性状、pH、不溶微粒、紫外-可见吸收光谱、硝普钠含量等。结果避光套避光，在20℃或35℃时，注射用硝普钠与氯化钠注射液混合后26h内是稳定的；不避光任何条件下溶液均不稳定；溶液的稳定性与浓度及温度无关，与光照和强度与时间密切相关。结论在避光条件下，注射用硝普钠与氯化钠注射液配伍26h内稳定。

Study on Compatible Stability of Nitroprusside Sodium for Injection with Sodium Chloride Injection

Objective To investigate the compatible stability of nitroprusside sodium for injection（SNP） when mixedwith sodium chloride injection. Methods SNP was prepared into solution according to clinical use. The stability ofSNP solution was studied in different environment and at different time, including appearance, pH value, insoluble particle,ultraviolet-visible absorption and SNP content. Results SNP solutions of sodium chloride injection were stable for26 hours after preparation in shading circumstances at 20℃ or 35℃ .Under the direct incandescent lamp withoutlightproof covering or shading circumstances, the solution was very unstable. Conclusion In the dark condition, SNP wasstable within 26h after mixing with sodium chloride injection.