基于死因监测青岛市居民2008-2012年原发性肝癌死亡分析

目的 发展中国家的肝癌发病率呈现下降趋势,但中国的肝癌疾病负担仍然严重,本研究旨在通过分析青岛市2008-2012年居民肝癌死亡情况及其流行特征,为进一步制定肝癌防控措施提供科学依据.方法 运用Excel和SPSS 21.0统计软件对青岛市2008-2012年死因监测系统的肝癌死亡病例数据进行整理和分析,计算其粗死亡率、标化死亡率、年度变化百分比(annual percent change,APC),描述其3者间分布特征.结果 2008-2012年青岛市居民死于肝癌13 004例,其中男9 554例,女3 450例;肝癌粗死亡率为33.99/10万,标化死亡率为27.98/10万;男性肝癌死亡率为49.89/10万,高于女性的18.06/10万,是女性肝癌死亡率的2.8倍.经标化后,男性死亡率(41.19/10万)是女性(14.42/10万)的2.9倍.肝癌标化死亡率从2008年的35.66/10万下降到2012年的20.21/10万,下降了43.33%,通过时间趋势分析,差异有统计学意义,P<0.05;5年来肝癌在恶性肿瘤死因顺位中一直居于第2位,仅次于肺癌.各时期随年龄的增长肝癌死亡率随之增加,死亡率有城乡差异,农村标化死亡率为30.98/10万,高于城市的18.69/10万,城乡死亡率比为1:1.66.结论 5年来肝癌总死亡率呈下降趋势,差异有统计学意义,死亡率男性高于女性,农村高于城市,肝癌死因顺位居第2位,其仍是青岛市城乡居民恶性肿瘤死亡的主要原因,男性、农村及高龄人群是当前肿瘤防治工作的重点.

Mortality analysis of primary liver cancer in Qingdao city residents during 2008-2012 based on the cause of death

OBJECTIVE In developing countries the incidence of liver cancer showed a downward trend,but liver disease burden in China is still serious,this study aims to analyze the death of liver cancer in Qingdao city from 2008 to 2012 and its epidemic characteristics in Qingdao city,and provide scientific basis for the further development of cancer prevention and control measures.METHODS Using Excel and SPSS 21.0 statistical software to collate and analyze the data of liver cancer deaths in Qingdao city,2008-2012.The crude mortality rate,Standardized mortality rate,annual percent change(APC) were calculated,its demographic characteristics were described.RESULTS In 2008-2012,13 004 patients died of liver cancer in Qingdao,including 9 554 males and 3 450 females.Liver cancer crude mortality rate was 33.99/105,standardized mortality rate was 27.98/105.Male liver cancer mortality rate (49.89/105) was higher than that of female rate(18.06/105),which was 2.8 times as much as that of female liver cancer.After standardization,male (41.19/105)were 2.9 times as female(14.42 million).Standardized mortality rate of liver cancer from 35.66/105 in 2008 fell to 20.21/105 in 2012,a decrease of 43.33%.Through time trend analysis,the difference was statistically significant (P<0.05).Liver cancer in the cause of the death of cancer had been living in second place five years,second only to lung cancer.Liver cancer mortality increases with age.Mortality differences between urban and rural areas showed that the rural Standardized mortality rate (30.98/105) was higher than that of city (18.69/105),rather than for the 1:1.66 death in urban and rural areas.CONCLUSIONS In the 5 years,the total mortality rate of liver cancer was decreased,the change was statistically significant.Mortality was higher in males than that in females,and higher in rural areas than in cities;death cause of liver cancer ranked the second.It is still the main cause of death of malignant tumor among urban and rural residents in Qingdao city;male,rural and elderly population are the focus of the current cancer prevention and control work.