戒烟对慢性阻塞性肺疾病患者肺功能和生活质量的影响

目的探讨戒烟对慢性阻塞性肺疾病(COPD)患者肺功能和生活质量的影响。方法对2008年12月-2009年12月在承德医学院附属医院呼吸科接受诊治的吸烟的COPD患者实施医生"劝导戒烟干预",干预时间为2个月。根据戒烟成功与否,将其分为戒烟组(36人)、吸烟组(28人),同期接受诊治的有吸烟史但已戒烟2年以上的COPD患者为曾吸烟组(26人),每隔3个月检测其第一秒呼气容积(FEV1)、用力肺活量(FVC)、呼气峰值流速(PEF),12个月后采用CAT评定量表对其生活质量进行测定。结果随访3个月后,戒烟组一氧化碳血红蛋白结合百分比(COHb%)较入组(0个月)时显著降低(P<0.05)。FEV1、FVC在各时间点戒烟组和吸烟组均高于曾吸烟组,差异有统计学意义(P<0.05)。随访12个月时,戒烟组FEV1、FVC均高于吸烟组,但差异无统计学意义;PEF较0个月时增高37ml,差异有统计学意义(P<0.05)。CAT显示,吸烟组痰量高于戒烟组和曾吸烟组(P<0.05)。结论戒烟可以提高COPD患者FEV1、FVC、PEF及其生活质量。

The Effect of Smoking Cessation on Pulmonary Function and Life Quality in COPD Patients

Objective To investigate the effect of smoking cessation on pulmonary function and life quality in COPD patients.Methods 90 COPD patients with smoking history were conducted a 12-month follow-up during October 2008 to October 2009 in the department of respiratory disease in the affiliated hospital of Chengde Medical College,and were divided into 3 groups:smoking cessation group(n=36),smoking group(n=28)and ex-smoking group(n=26)based on the smoking status and on the results of 2-months long intervention of smoking cessation advice by physicians.All of the subjects were taken examination of pulmonary function at every 3 months,and the life qualities were summarized with CAT scale at the end of the 12th month.Results At the end of 3 months follow-up,the binding percentage of hemoglobin with CO(COHb%)decreased significantly than that on the beginning of the follow-up in the smoking cessation group(P<0.05);FEV1 and FVC were higher in smoking cessation group and smoking group than those in ex-smoking group(P<0.05).At the end of the 12th month of the follow-up,FEV1 and FVC were higher in smoking cessation group than in smoking group,but was not significant;and PEF was 37 ml higher than that on the beginning of the follow-up in smoking cessation group.CAT results showed that sputum volume was higher in smoking group than in other two groups(P<0.05).Conclusion Smoking cessation can alleviate pulmonary function aggravation and improve the life quality.