舒通安胶囊对海洛因依赖者血单胺类递质的影响

目的:了解5-羟色胺(5-HT)、5-羟吲哚乙酸(5-HIAA)、多巴胺(DA)、去甲肾上腺素(NE)在海洛因依赖发病中的意义,观察舒通安胶囊对海洛因依赖者单胺类递质的影响。方法:用荧光分光光度法检测56例海洛因依赖者(注射组35例、烫吸组21例)治疗前后和23例正常人血浆及血小板5-HT、5-HIAA、DA和NE含量。结果:海洛因依赖者血浆5-HT、5-HIAA、DA和NE含量均高于对照组(P<0.01),烫吸组血浆DA、5-HIAA含量低于注射组(P<0.05,P<0.01),经舒通安胶囊治疗后血浆5-HT、5-HIAA、DA和NE含量显著降低(P<0.01),其中烫吸组NE高于注射组(P<0.05)。海洛因依赖者血小板5-HT、5-HIAA、DA和NE含量均高于对照组(P<0.01),烫吸组血小板5-HT、DA含量低于注射组(P<0.01),经舒通安胶囊治疗后血小板5-HT、5-HIAA、DA和NE含量显著降低(P<0.01),其中烫吸组DA、5-HT、NE高于注射组(P<0.01,P<0.05)。结论:单胺类递质在海洛因依赖的病理过程可能有重要意义,舒通安胶囊可调节海洛因依赖者外周单胺类递质水平。

Effect of Shutong''''an Capsule on Blood Monoamine Neurotransmitter in Heroin Dependent Patients

Objective: To investigate the changes of monoamine neurotransmitter level in plasma and platelet after treatment with Shutong'an Capsule (STAC) in heroin addicts. Methods: 5-HT, 5-HIAA, DA and NE were determined by fluorescence spectrophotometry. The plasma and platelet were collected from the heroin addicts (35 cases by injecting and 21 by smoking) and compared with 23 samples of normal controls. Results: The plasma levels of 5-HT, 5-HIAA, DA and NE were higher in heroin addicts compared with normal controls, and reduced after treatment with STAC. The plasma levels of 5-HIAA, DA were lower and NE were higher in smoking heroin addicts than that of injecting drug users. The platelet levels of 5-HT, 5-HIAA, DA and NE were significantly higher in heroin addicts and reduced after treatment with STAC. The platelet levels of 5-HT, DA were lower and after treatment with STAC DA, 5-HT and NE levels were higher in smoking addicts than injecting drug users. Conclusion: The monoamine neurotransmitter might play an important role in the pathogenesis of heroin dependence. STAC could regulate the monoamine levels in heroin addicts.