侵袭性真菌感染实验诊断的研究进展

近年来,随着大量广谱抗生素、皮质激素、高强度免疫抑制剂和大剂量化疗药物的应用.造血干细胞移植、实体器官移植和艾滋病患者的增加,侵袭性真菌感染(IFI)逐年增多,其发病率和病死率居高不下.真菌感染的实验室诊断已成为诊断IFI的重要依据,同时病原真菌的实验室鉴定也具有指导临床治疗以及流行病学研究的双重意义.此文就近年来IFI实验诊断方面的研究进展作了综述.

Advances in laboratory diagrams of invasive fungal infection

In recent years, with the applications of broad-spectrum antibiotics, corticosteroids, high-intensity immunosuppressive agents and high-dose chemotherapy, hematopoietic stem cell transplantation solid organ transplant and the increasing number of AIDS patients, invasive fungal infection(IFl) is increasing year by year, and its high morbidity and mortality harm to human health seriously. Laboratory diagnosis of fungal infection become an important evidence of diagnosing In, at the same time, identifying pathogenic fungus can guide clinical treatment and be the significance of epidemiological studies. In this review, the last advances in laboratory diagnosis of IFI are described.