Graves病病人神经电生理研究

目的 探讨Graves病病人运动及感觉神经电生理改变。方法 对46例Graves病病人和30例正常对照组检测正中和胫后神经感觉神经传导速度（SCV）、运动末端潜伏期（ML）、复合肌肉动作电位（CMAP）的波幅及F波潜伏期和出现率。结果 Graves病组神经传导改变43例（93．5％），其中胫后感觉神经波幅降低33例（71．7％，P＜0．001）；正中神经和胫后神经运动传导改变分别4例（8．6％）和8例（17．3％），与正常对照组比较差异均无显著意义（P＞0．05）；正中神经及胫后神经F波异常分别17例（36．9％）和14例（30．4％），6例病人同时表现F波和运动神经传导异常。结论 神经电生理检查较自觉症状和体征敏感，下肢感觉神经损害最常见，运动神经元以近端受损为主。

The studies of the nervous electrophysiology in Graves' disease patients

Objective To investigate the changes of motor and sensory nervous electrophysiology in Graves' disease.Methods The sensory conduction velocity(SCV),motor distal latency(ML),compound muscle action potential(CMAP),F wave latency and F wave occurrence rate were detected in median nerves and posterior tibial nerves in 46 patients with Graves' disease and 30 healthy individuals.Results The nerve conduction velocity abnormality was 43 cases(93.5%) with Graves disease group,decrease of SCV 33 cases(71.7%,P<0.001).In median nerves and posterior tibial nerves,the abnormality of motor conduction were 4 cases(8.6%) and 8 cases(17.3%) respectively(both showing P>0.05),the abnormality of F wave were 17(36.9%) and 14(30.4%) respectively.The abnormality of F wave and the motor conduction were noted in 6 patients at the same time.Conclusion Nervous electrophysiology examination is more sensitive than symptom and sign;the damage of lower extremity nerve is very common,and the damage of proximal motor neuron was more frequently.