The streptokinase domain responsible for plasminogen binding |
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| Affiliation: | 1. Faculty of Computer Science, Benemérita Universidad Autónoma de Puebla (BUAP), Av. San Claudio #14, Puebla 72592, México;2. Computer Science Department, Instituto Nacional de Astrofísica Óptica y Electrónica (INAOE), Luis Enrique Erro #1, Puebla 72840, México;1. School of Computer Science, University of Nottingham, Nottingham, UK;2. Mathematics Department, Faculty of Science, University of Assiut, Assiut, Egypt;3. Laboratory of Image & Data Analysis, Ilixa Ltd., Nottingham, UK;4. Faculty of Medicine, M.K. Ciurlionio 21, LT-03101 Vilnius University, Vilnius, Lithuania;5. National Center of Pathology, affiliate of Vilnius University Hospital Santaros Clinics, P. Baublio 5, LT-08406 Vilnius, Lithuania;6. Nottingham Molecular Pathology Node and Academic Unit of Pathology, Division of Cancer and Stem Cells, University of Nottingham, Queen''s Medical Centre, Nottingham, UK |
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| Abstract: | ![]()
The limited proteolysis of soluble recombinant streptokinase by Sepharose-immobilized human plasmin(ogen) complexed with recombinant streptokinase is described. A 17 kDa streptokinase fragment comprising residues Val143 (Glu148) to Arg289 (Lys293) has been shown to be the smallest stable plasminogen binding domain. Moreover, this region seems also to be important for plasminogen activation. |
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