p27基因在豫北地区食管鳞癌发生发展过程中的表达及意义

目的 :系统对比探讨p2 7基因在豫北地区食管鳞癌发生发展过程中的表达及临床病理意义。方法 :应用免疫组织化学 (S -P法 )检测 72例食管鳞癌标本 (每例均包括正常食管黏膜、非典型增生和浸润癌 )中p2 7基因的表达 ,并分析其临床病理意义。结果 :p2 7基因在非典型增生和浸润癌的表达明显低于正常黏膜上皮 (P <0 .0 1) ;p2 7基因表达与淋巴结转移密切相关 (P <0 .0 5 ) ;与浸润深度亦显示一定的相关趋势 (X2 =3.80 ) ,但与组织学分级、年龄和性别无明显相关关系 (P >0 .0 5 )。结论 :p2 7基因表达异常在豫北地区食管鳞癌发生发展过程具有重要意义 ,并与食管鳞癌的转移等恶性行为相关 ,可作为豫北地区食管鳞癌早期诊断和判断预后的重要分子指标。

Expression of the p27 gene in human esophageal squamous cell carcinogenesis of northern of Henan and its significances

Objective:To study expression of the p27 gene in human esophageal squamous cell carcinogenesis of northern of Henan and its significances. Methods:Paraffin sections from 72 patients were examined by immunohistochemical staining (s-p method) with the monoclonal antibody.Results: The expressions of p27 in atypical hyperplasia and invasive carcinoma was significantly lower than normal esophageal mucosae (p<0.01). A dramatically relationship was seen between the abnormal expression of p27 and lymph nodes metastasis(p<0.05). A tendency relationship was found between the abnormal expression of p27 and invasive depth(x2=3.80). Conclusions: These data indicated that, the abnormal expression of p27 correlates with esophageal squamous cell carcinogenesis and malignant biological behavior. It may be an early event in the development of esophageal squamous cell carcinoma and may have a prognostic importance . Thus it could be used as important molecular maker in early diagnosis and prognosis.