胰岛素联合唑来膦酸治疗糖尿病骨质疏松症对患者血清指标的影响

目的 分析胰岛素联合唑来膦酸治疗对糖尿病骨质疏松（DOP）患者血糖血脂以及骨代谢指标的影响。方法 选择2016年12月~2019年4月于我院诊治的DOP患者共136例进行研究，采用随机数字表法分为对照组和实验组，每组68例，对照组采用二甲双胍联合唑来膦酸治疗，实验组采用胰岛素联合唑来膦酸治疗，比较两组干预后血脂水平（TG、TC、LCL-C、HDL-C）、血糖指标（空腹、餐后2h、糖化血红蛋白）以及骨代谢相关指标（BAP、TRAP-5b、BGP以及s-CTX）。结果 治疗后实验组空腹、餐后2h血糖及HbA1c均低于对照组（P＜0.05）；实验组治疗后TG、TC、LCL-C、HDL-C水平均低于对照组（P＜0.05）；实验组BAP、BGP水平均高于对照组（P＜0.05）；实验组TRAP-5b水平均低于对照组（P＜0.05）；两组s-CTX指标比较，差异无统计学意义（P＞0.05）。结论 对DOP患者使用胰岛素与唑来膦酸联合治疗方案，有助于改善患者的血脂以及血糖水平，同时利于患者骨骼骨质的沉积，值得临床应用。

Effect of Insulin Combined with Zoledronic Acid on Serum Markers in Patients with Diabetic Osteoporosis

Objective To analyze the effect of insulin combined with zoledronic acid on blood glucose, blood lipids and bone metabolism in patients with diabetic osteoporosis (DOP). Methods A total of 136 patients with DOP who were treated in our hospital from December 2016 to April 2019 were enrolled in the study. They were randomly divided into the control group and the experimental group, 68 in each group. The control group was treated with metformin and zoledron. Acid treatment, the experimental group was treated with insulin combined with zoledronic acid, blood lipid levels (TG, TC, LCL-C, HDL-C), blood glucose levels (fasting, 2h postprandial, glycated hemoglobin) and bone metabolism were compared between the two groups. Related indicators (BAP, TRAP-5b, BGP, and s-CTX). Results After treatment, the fasting, 2h postprandial blood glucose and HbAlc in the experimental group were lower than the control group(P<0.05). The TG, TC, LCL-C and HDL-C levels in the experimental group were lower than those in the control group(P<0.05); the BAP and BGP levels in the experimental group were higher than those in the control group(P<0.05); the TRAP-5b level in the experimental group was lower than that in the control group(P<0.05); the difference of s-CTX between the two groups, the difference was not statistically significant (P>0.05). Conclusion The combination of insulin and zoledronic acid in patients with DOP can improve the blood lipid and blood glucose levels of patients, and it is beneficial to the deposition of skeletal bone. It is worthy of clinical application.