胶质母细胞瘤信号通路的研究

胶质母细胞瘤（GBM）是胶质瘤中恶性程度最高的脑部肿瘤，其死亡率和复发率较高。目前GBM发生发展机制尚不明确，无特效治疗手段。常见的治疗方法有手术切除、放疗及化疗等，但其预后差，因此寻找GBM相关信号通路可为了解其发病机制、靶向治疗提供指引。目前，研究发现p53途径、MAPK途径、PI3K/AKT途径以及Notch途径是参与GBM的重要通路；除此之外，还有其他的信号通路也陆续被发现。本文通过对p53信号通路、MAPK信号通路、PI3K/AKT信号通路、Notch信号通路以及其他信号通路在GBM中的作用进行综述，旨在为临床治疗GBM提供参考。

Study on Glioblastoma Signaling Pathway

Glioblastoma (GBM) is the most malignant brain tumor in glioma, with a high mortality and recurrence rate. At present, the mechanism of development of GBM is still unclear, and there is no specific treatment. Common treatment methods include surgical resection, radiotherapy and chemotherapy, but its prognosis is poor. Therefore, finding a signal pathway related to GBM can provide guidance for understanding its pathogenesis and targeted therapy. At present, the study found that the p53 pathway, MAPK pathway, PI3K/AKT pathway and Notch pathway are important pathways involved in GBM; in addition, other signaling pathways have been discovered. This article reviews the role of p53 signaling pathway, MAPK signaling pathway, PI3K/AKT signaling pathway, Notch signaling pathway and other signaling pathways in GBM, aiming to provide reference for clinical treatment of GBM.