曲美他嗪治疗老年冠心病心力衰竭的疗效及其对患者炎症因子的影响

目的 探讨美托洛尔联合曲美他嗪治疗老年冠心病心力衰竭的疗效。方法 收集我院自2016年8月~2018年9月收治的76例冠心病心力衰竭患者，按随机数字表法分为观察组和对照组，各38例。两组均给予标准化心力衰竭治疗方案治疗，对照组加服酒石酸美托洛尔片治疗，观察组在对照组基础上联合曲美他嗪片治疗，比较两组治疗前后超敏C反应蛋白（hs-CRP）、白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平及临床疗效。结果 治疗后，两组hs-CRP、IL-6、TNF-α水平均下降，且观察组低于对照组，差异有统计学意义（P＜0.05），观察组总有效率为92.11%，高于对照组的73.68%，差异有统计学意义（P＜0.05）。结论 美托洛尔联合曲美他嗪能够有效提高老年冠心病心力衰竭患者心功能，减轻机体炎症反应。

Efficacy of Trimetazidine in the Treatment of Elderly Patients with Coronary Heart Disease and Its Effect on Inflammatory Factors

bstract:Objective To investigate the efficacy of metoprolol combined with trimetazidine in the treatment of elderly patients with coronary heart disease and heart failure. Methods 76 patients with coronary heart disease who were admitted to our hospital from August 2016 to September 2018 were enrolled in the study. They were divided into observation group and control group according to the random number table, 38 cases each. Both groups were treated with standardized heart failure treatment. The control group was treated with metoprolol tartrate tablets. The observation group was treated with trimetazidine tablets on the basis of the control group,The levels of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and clinical efficacy were compared before and after treatment. Results After treatment, the levels of hs-CRP, IL-6 and TNF-α in the two groups decreased, and the observation group was lower than the control group,the difference was statistically significant (P<0.05). The total effective rate of the observation group was 92.11%, which was higher than that of the control group 73.68%,the difference was statistically significant (P<0.05). Conclusion Metoprolol combined with trimetazidine can effectively improve the heart function and reduce the body's inflammatory response in elderly patients with coronary heart disease and heart failure.