双水平无创正压通气对急诊Ⅱ型呼吸衰竭并心衰患者NT-proBNP及CRP的影响

目的 探讨双水平无创正压通气治疗Ⅱ型呼吸衰竭并心衰患者的临床效果。方法 选取我院2016年3月~2018年4月在急诊治疗的92例Ⅱ型呼吸衰竭并心衰患者资料进行分析，根据患者救治过程中是否采用双水平无创正压通气治疗分为观察组56例（基础治疗+双水平无创正压通气），对照组36例（仅采取基础治疗），比较两组的动脉血氧分压（PaO2）、动脉血二氧化碳分压（PaCO2）、pH值、氧供（DO2）、氧耗（VO2）、左室射血分数（LVEF%）、每搏输出量（SV）、心肌做功指数（TEI）、血浆氨基末端脑钠肽前体（NT-proBNP）、血清C反应蛋白（CRP）。结果 治疗后，观察组PaO2、pH值、DO2、VO2水平均高于对照组，PaCO2水平均低于对照组（P＜0.05）；观察组患者的LVEF%、SV指数水平均高于对照组，TEI水平均低于对照组（P＜0.05）；治疗后，观察组NT-proBNP、CRP水平均低于对照组（P＜0.05）。结论 双水平无创正压通气治疗Ⅱ型呼吸衰竭并心衰患者有助于改善患者的血气指标、心功能、降低NT-proBNP及CRP水平。

Effect of Bi-level Noninvasive Positive Pressure Ventilation on NT-proBNP and CRP in Patients with Emergency Type II Respiratory Failure and Heart Failure

Objective To investigate the clinical effects of bi-level noninvasive positive pressure ventilation in patients with type II respiratory failure and heart failure. Methods A total of 92 patients with type II respiratory failure and heart failure who were treated in the emergency department from March 2016 to April 2018 in our hospital were selected. According to whether patients were treated with bi-level non-invasive positive pressure ventilation during treatment, 56 patients (basic treatment+ double-level non-invasive positive pressure ventilation) and 36 patients in the control group (basic treatment only) were compared. Partial pressure (PaO2), arterial blood carbon dioxide partial pressure (PaCO2), pH value, oxygen supply (DO2), oxygen consumption (VO2), left ventricular ejection fraction (LVEF%), stroke volume (SV), myocardial work Index (TEI), plasma amino terminal brain natriuretic peptide precursor (NT-proBNP), serum C-reactive protein (CRP). Results After treatment, the PaO2, pH, DO2, and VO2 levels in the observation group were higher than those in the control group, and the PaCO2 level was lower than that in the control group(P<0.05). The LVEF% and SV index of the observation group were average. Compared with the control group, the TEI level was lower than that of the control group(P<0.05). After treatment, the NT-proBNP and CRP levels in the observation group were lower than the control group(P<0.05).Conclusion Bi-level non-invasive positive pressure ventilation in patients with type II respiratory failure and heart failure can improve blood gas parameters, cardiac function and reduce NT-proBNP and CRP levels.