|
|||||
|
|
| 蝙蝠葛碱对实验性心肌缺血再灌注损伤的保护作用 | |
| 引用本文： | 李明阳 李儒汉. 蝙蝠葛碱对实验性心肌缺血再灌注损伤的保护作用[J]. 军医进修学院学报, 1993, 14(3): 200-203 |
| 作者姓名： | 李明阳 李儒汉 |
| 作者单位： | 空军总医院，医进修学院内科十七病室 研究生 |
| 摘 要： | 本文以家兔为实验对象,开胸结扎冠状动脉左室支中点90分钟,再灌注3小时,形成心肌缺血再灌注模型。以梗塞面积大小、中性粒细胞浸润程度、心肌组织超氧化物歧化酶(SOD)活力和丙二醛(MDA)含量为主要观察指标,观察了蝙蝠葛碱对心肌缺血再灌注损伤的作用。结果表明,蝙蝠葛碱通过抑制中性粒细胞在缺血再灌注心肌中的浸润,保护心肌SOD活力,减少心肌MDA含量,缩小梗塞面积,对心肌缺血再灌注损伤具有明显的保护作用。 |
| 关 键 词： | 心肌缺血 再灌注损伤 中性粒细胞 异喹啉类 |
The Protective Effects of Dauricine on Experimental Ischemia-Reperfusion Induced Myocardial Injury in Rabbits |
|
| Li Mingyang Li Ruhan. The Protective Effects of Dauricine on Experimental Ischemia-Reperfusion Induced Myocardial Injury in Rabbits[J]. Academic Journal of Pla Postgraduate Medical School, 1993, 14(3): 200-203 | |
| Authors: | Li Mingyang Li Ruhan |
| Affiliation: | Li Mingyang Li Ruhan |
| Abstract: | The effects of Dauricine on ischemia-reperfusion induced myocardial injury in rabbits was studied. Dauricine reduced infarct size, protected myocardial SOD activities, decreased myocardial MDA content and reduced myocardial ultrastructure damage. These results suggested that Dauricine could protect ischemia-reperfusion induced myocardial injury. It may be mediated through inhibition of neutrophils infiltration into ischemia-reperfusion myocardium and decrease production of oxygen-derived free radicals. |
| Keywords: | Myocardial ischemia Reperfusion injury Neutrophils Isoquiuolines |
| 本文献已被 CNKI 维普 等数据库收录！ | |