IMP3蛋白在乳腺癌中的表达及其临床意义

[目的]研究胰岛素样生长因子ⅡmRNA结合蛋白3(IMP3)在浸润性乳腺癌及其各分子亚型中的表达及其临床意义.[方法]收集189例浸润性乳腺癌组织标本,采用免疫组织化学法检测ER、PR和Her-2的表达情况,并据此将乳腺癌患者分为腺腔A型、腺腔B型、Her-2过表达型和基底细胞样型.用免疫组织化学法测定4种分子亚型乳腺癌组织中IMP3的表达情况,并分析IMP3表达与乳腺癌患者临床病理特征的关系.[结果]18.5％浸润性乳腺癌组织中有IMP3表达.IMP3的表达与组织学分级、Ki-67指数有关(P＜0.01),组织学分级越高及Ki-67指数高者IMP3表达越高.IMP3在腺腔A型、腺腔B型、Her-2过表达型和基底细胞样型中表达率分别为5.3％、10.0％、21.4％和58.3％.Her-2过表达型的IMP3表达率高于腺腔A型,差异有统计学意义(P＜0.05).基底细胞样型表达率高于腺腔A型、腺腔B型及Her-2过表达型,差异有统计学意义(P＜0.001).IMP3阳性表达者生存率显著低于阴性表达者(P＜0.001).[结论]IMP3在基底细胞样型乳腺癌组织中高表达,其表达可作为乳腺癌预后的评估指标之一,并有可能成为基底细胞样型乳腺癌靶向治疗的一个新靶点.

Expression of IMP3 in Breast Cancer and Its Clinical Significance

[Purpose] To study the expression of insulin-like growth ⅡmRNA-binding protein 3 (IMP3) in invasive breast cancer and in different molecular subtypes cancer and its clinical significance. [Methods] A total of 189 invasive breast cancer samples were collected. Expression of ER, PR and Her-2 were detected by immnohistochemical method, and the samples were categorized as follows: luminal A, luminal B, Her-2 over-expression and basal-like subtypes. The expression of IMP3 in all molecular subtypes was detected by immunohistochemical method, and the correlation of IMP3 expression with patients’ clinicopathological feature was analyzed.[Results] The positive expression rate of IMP3 in invasive breast cancer was 18.5%. The expression of IMP3 correlated to histological grade and Ki-67 index, with significant difference (P<0.01). The positive rates were higher in those patients with higher histological grade or higher Ki-67 index. The positive rates of IMP3 in luminal A,luminal B, Her-2 over-expression and basal-like subtypes were 5.3%, 10.0%, 21.4% and 58.3%, respectively. The positive rate of IMP3 in Her-2 over-expression subtype was remarkablely higher than that in luminal A subtype ,with significant difference (P<0.05). The posi- tive rate of IMP3 in basal-like subtype was remarkablely higher than those in luminal A, luminal B and Her-2 over-expression subtypes (P<0. 001). The survival rate of patients with IMP3 positive- expression was significantly lower than that with negative-expression (P <0.001). [Conclusion] IMP3 is highly expressed in basal-like subtype of breast cancer and may be a useful indicator for evaluating the prognosis of breast cancer, and it may be a new target for targeted therapy.