瘢痕疙瘩的形成与Langerhans细胞的相关性研究

目的 探讨Langerhans细胞与瘢痕疙瘩形成的相关性。方法 应用免疫组织化学（ABC）法观察S-100蛋白在瘢痕疙瘩的浸润部、增生部、老化部与正常皮肤组织中表达。结果瘢痕疙瘩组织浸润部、增生部中S-100蛋白免疫反应阳性的Langerhans细胞明显增多。统计学处理：瘢痕疙瘩的增生部、浸润部与正常皮肤之间差异有显著性（P〈0．01），瘢痕疙瘩的浸润部、增生部、老化部差异有显著性（浸润部〉增生部〉老化部或正常皮肤（P〈0．01），而正常皮肤与瘢痕疙瘩老化部之间差异无显著性（P〉0．05）。结论 Langer—hans细胞在瘢痕疙瘩的形成过程中可能起到很重要的作用。

An immunohistochemical study of Langerhans cells on keloid

Objective To investigate the correlation between the Langerhans cells and the genesis of keloid. Methods Immunohistochemical chemical technique (ABC method) was performed to observe the expression of S-100 protein on invasive, proliferative and aged parts of keloid and normal skin. Results The number of langerhans cells in the part of keloid where the expression of S-100 protein was positive and significantly increased, compared with normal skin controls(P<0.01). The number also showed significant difference between invasive, proliferative and aged parts of keloid(invasive part>proliferative part>aged part or normal skin,P<0.01), while there were no significant difference between aged part of keloid and normal skin(P>0.05). Conclusion Langerhans cells may play an important role in keloid genesis.