原发性肝癌切除术后精准序贯介入治疗的临床疗效评价

目的探讨肝癌切除术后患者实施精准序贯介入治疗的临床疗效。方法对我院2005-2010年207例原发性肝癌术后患者81例采用常规序贯介入治疗。126例采用精准序贯介入治疗，对两组患者治疗情况进行对比分析研究。结果统计分析表明，精准序贯介入治疗组与常规序贯介入治疗组在年龄、手术时间、术中失血、同术期输血量及术后并发症发生率方面差异均无统计学意义（P〉0．05）。两组患者均可在介入治疗后显著降低术后6个月及12个月的AFP值（P〈0．05）船在反应肝功能的ALT、ALB及Child-Pijgh评分方面，精准序贯介入治疗组嚷现出对介入治疗良好的耐受性，治疗前后比较，差异无统计学意义（P〉0．05）。精准序贯介入治疗组1、2、3年的肿瘤复发率分别为16．67％、22．34％、26．76％，常规序贯介入治疗组术后1、2、3年的肿瘤复发率分别为30．86％、36．88％、47．82％，两组之间比较差异有统计学意义（P〈0．05）；精准序贯介入治疗组术后1、2、3年的生存率分别为87.30％、84．26％、78．87％，常规序贯介入治疗组术后1、2、3年生存率分别为76．54％、72．34％、60．87％，两组比较差异有统计学意义（P〈0．05）。结论对原发性肝癌切除术后实施精准序贯介入治疗，在有效控制肿瘤复发的基础上，能够最大限度保护肝脏功能，有利于提高患者生存率。

Evaluation of clinical therapeutic effect of precise sequential intervention therapy after primary liver cancer hepatectomy

Objective To investigate the clinical effects of precise sequential intervention therapy after primary liver cancer hepatectomy.Methods 207 cases of patients underwent primary liver cancer hepatectomy from 2005 to 2010 in our hospital from 2005 to 2010 were investigated,81 cases were treated with conventional sequential intervention(conventional sequential intervention group),126 cases were treated with precise sequential intervention(precise sequential intervention group).The clinical effect of the two groups were compared.Results Statistical analysis showed that there were no significant differences in the age,operating time,intraoperatie blood loss,perioperative blood transfusion and complications between the two groups(P > 0.05).Serum AFP level significantly decreased in the two groups after intervention therapy in 6 months and 12 months(P < 0.05).The precise sequential intervention group showed a well tolerance on the intervention treatment,compared with before treatment,there were no significant differences in ALT,ALB and Child-Pügh scores(P > 0.05).The tumor recurrence rates and the survival rates of 1,2,3 years of the precise sequential therapy group were 16.67%,22.34%,26.76% and 87.30%,84.26%,78.87%,which of the conventional sequential intervention group were 30.86%,36.88%,47.82% and 76.54%,72.34%,60.87% respectively,the differences were statistically significant(P < 0.05).Conclusion Adopting precise sequential intervention therapy after primary liver cancer hepatectomy can protection liver function maximumly on the basis of control tumor recurrence,which can improve the survival rate of patients.