盐酸帕洛诺司琼对预防含顺铂方案化疗所致恶心呕吐患者的疗效观察

目的探讨分别应用盐酸帕洛诺司琼、盐酸格拉司琼预防含顺铂方案化疗所致恶心呕吐的疗效。方法将60例接受含顺铂方案化疗的肿瘤患者随机分为观察组（盐酸帕洛诺司琼组）及对照组（盐酸格拉司琼组）,每组各30例,比较两组对预防化疗所致呕吐的临床疗效、用药后不同时间恶心的完全控制率以及恶心治疗后的有效率。结果观察组急性呕吐的总有效率（83.3%）明显高于对照组（66.7%）,两组延迟性呕吐的总有效率分别为70.0%和53.3%,差异有统计学意义（χ2=14.127,P〈0.05）。用药后的第7天,第15天,观察组恶心的完全控制率明显高于对照组（χ2=6.237、11.248,P〈0.05）。用药后第15天,观察组对恶心治疗的有效率明显高于对照组（χ2=12.469,P〈0.05）。两组不良反应比较无显著性差异（P〉0.05）。结论盐酸帕洛诺司琼在预防含顺铂方案化疗所引起的恶心呕吐的疗效优于盐酸格拉司琼,安全性好,值得临床推广。

Effect observation of Palonosetron hydrochloride on preventing nausea and vomiting with chemotherapy including cisplatin

Obejective To investigate and compare effects of Palonosetron hydrochloride and granisetron hydrochloride were used to prevent the nausea and vomiting caused by chemotherapy with cisplatin.Methods 60 patients receiving chemotherapy including cisplatin were randomly divided into the observation group(palonosetron hydrochloride Group)and the control group(granisetron hydrochloride group),each group contained 30 cases.The occurrence of acute emesis,delayed vomiting,and Nausea complete control rate,nausea treatment efficiency after treatment different times were compared between two groups.Results The acute vomiting total effective rate in observation group(83.3%) was significantly higher than the control group(66.7%).Delayed vomiting total efficiency of two groups was 70.0% and 53.3% respectively,the difference was statistically significance(χ2=14.127,P < 0.05).After medication 7 days,15 days,the full control of nausea rate in the observation group was significantly higher than the control group(χ2=6.237,11.248,P < 0.05).After Medication 15 days,the efficacy rate for nausea treatment in the observation group was significantly higher than the control group(χ2=12.469,P <0.05).Two sets of adverse reactions was no significant difference(P > 0.05).Conclusion The efficacy of Palonosetron hydrochloride in the prevention and treatment of nausea and vomiting caused by chemotherapy including cisplatin is superior to the efficacy of aranisetron hydrochloride,and Palonosetron hydrochloride has its own priorities,such as convenient use,good safety and worthy of clinical application.