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| 肿瘤相关巨噬细胞与肿瘤细胞上皮间质转化关系的研究进展 | |
| 引用本文： | 张娟,王鹏,刘鲁明. 肿瘤相关巨噬细胞与肿瘤细胞上皮间质转化关系的研究进展[J]. 中国癌症杂志, 2012, 22(4): 307-311 |
| 作者姓名： | 张娟 王鹏 刘鲁明 |
| 作者单位： | 1. 上海中医药大学研究生院,上海,201203 2. 复旦大学附属肿瘤医院中西医结合科,复旦大学上海医学院肿瘤学系,上海,200032 3. 上海中医药大学研究生院,上海,201203;复旦大学附属肿瘤医院中西医结合科,复旦大学上海医学院肿瘤学系,上海,200032 |
| 摘 要： | 上皮间质转化(epithelial-mesenchymal transition,EMT)是上皮细胞在形态学上发生向间质细胞表型的转变,在肿瘤的侵袭和转移过程中发挥重要作用,肿瘤相关巨噬细胞(tumor-associatedmacrophage,TAM)是肿瘤的基本成分之一,通过分泌TNF-α、IL-6、EGF、VEGF、MMP-9、uPA等因子诱导肿瘤细胞发生EMT,协同其刺激新生血管形成、降解基质、促进肿瘤细胞发生局部侵袭及远处转移. |
| 关 键 词： | 肿瘤相关巨噬细胞 上皮间质转化 转移 |
Progress in the relationships of tumor-associated macrophage and epithelial-mesenehymal transition |
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| ZHANG Juan , WANG Peng , LIU Lu-ming. Progress in the relationships of tumor-associated macrophage and epithelial-mesenehymal transition[J]. China Oncology, 2012, 22(4): 307-311 | |
| Authors: | ZHANG Juan WANG Peng LIU Lu-ming |
| Affiliation: | (The Graduate School of Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China) |
| Abstract: | Epithelial-mesenchymal transition(EMT) is the process of conversion of epithelial to mesenchymal phenotype.EMT is very important in tumor invasion and metastasis.Tumor-associated macrophage(TAM),the basic component of tumor,induces the EMT of tumor cells.In addition to stimulating angiogenesis and extracellular matrix degradation,TAM is responsible for tumor local invasion and distant metastasis. |
| Keywords: | Tumor-associated macrophage Epithelial-mesenehymal transition Metastasis |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |