| 国产“万古霉素”主要成分的结构鉴别 |
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| 引用本文： | 凌大奎,周玉,陈苏.国产“万古霉素”主要成分的结构鉴别[J].药学学报,1986,21(3):208-212. |
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| 作者姓名： | 凌大奎 周玉 陈苏 |
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| 作者单位： | 卫生部药品生物制品检定所,华北制药厂 北京,石家庄 |
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| 摘 要： | 国产“万古霉素”华北制药厂自投产至今已有十多年的历史,但与国外万古霉素相比,显示的生物效价与色谱行为不完全相同。经核磁共振(1HNMR和13CNMR)、快原子轰击质谱(FABMS)及其水解产物的分析测定,表明国产“万古霉素”分子中不含N-甲基亮氨酸而只含亮氨酸。分子的其余结构部分与万古霉素完全相同。从而证明国产“万古霉素”实际上是N-去甲基万古霉素。
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| 关 键 词： | N-去甲基万古霉素 万古霉素 |
| 收稿时间： | 1985-09-03 |
STUDIES ON THE STRUCTURE OF THE MAIN CONSTITUENT OF THE "VANCOMYCIN" MADE IN CHINA |
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| LING Da-Kui,ZHOU Yu and CHEN Su.STUDIES ON THE STRUCTURE OF THE MAIN CONSTITUENT OF THE "VANCOMYCIN" MADE IN CHINA[J].Acta Pharmaceutica Sinica,1986,21(3):208-212. |
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| Authors: | LING Da-Kui ZHOU Yu and CHEN Su |
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| Abstract: | More than ten years have passed, since Chinese "vancomycin" was produced by North China Pharmaceutical Corporation. Comparing with typical vancomycin, however, Chinese "vancomycin" shows some differences in antibacterial activity and chromatographic behaviour. Based on the data of nuclear magnetic resonance (~1HNMR and ~(13)CNMR), fast atom bombardment mass spectrum and its hydrolyzed products, it was confirmed that there is a leucine rather than a N-methyl-leucine in the molecule of Chinese "vancomycin", but all of the other residues are the same as that of vancomycin. Consequently, Chinese "vancomycin" is actually N-demethylvancomycin. |
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| Keywords: | N-demethylvancomycin Vancomycin |
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