| 联合化疗治疗多发性骨髓瘤临床分析 |
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| 引用本文： | 闫轶鹏. 联合化疗治疗多发性骨髓瘤临床分析[J]. 医药论坛杂志, 2010, 31(3): 1-2,6 |
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| 作者姓名： | 闫轶鹏 |
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| 作者单位： | 新乡医学院第一附属医院血液科,卫辉市,453100 |
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| 摘 要： | 目的探讨沙利度胺联合VAD方案治疗多发性骨髓瘤的可行性及安全性。方法将67例多发性骨髓瘤患者随机分为对照组32例和治疗组35例:对照组单用VAD方案化疗,治疗组在VAD方案基础上加用沙利度胺片,起始量100mg/d,每晚顿服或分早晚给药,根据患者耐受情况每2周增加100mg,最高剂量不超过600mg/d,维持此剂量6个月。观察两组临床疗效及不良反应。结果治疗组和对照组总有效率分别为82.9%和53.1%。两组总有效率比较,差异有统计学意义(P<0.05)。两组均无明显肝、肾功能损害及骨髓抑制,不良反应在对症处理后,症状均较快缓解。两组间不良反应比较,差异无统计学意义(P>0.05)。结论沙利度胺联合VAD方案治疗多发性骨髓瘤具有耐受性好、疗效肯定、不良反应少等优点,值得临床推广应用。
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| 关 键 词： | 多发性骨髓瘤 沙利度胺 VAD 化疗 |
Clinical Analysis of Combination Chemotherapy Treatment of Multiple Myeloma |
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| YAN Yipeng The First Affiliated Hospital of Xinxiang Medical College,Xinxiang ,China. Clinical Analysis of Combination Chemotherapy Treatment of Multiple Myeloma[J]. Journal of Medical Forum, 2010, 31(3): 1-2,6 |
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| Authors: | YAN Yipeng The First Affiliated Hospital of Xinxiang Medical College Xinxiang China |
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| Affiliation: | YAN Yipeng The First Affiliated Hospital of Xinxiang Medical College,Xinxiang 453100,China |
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| Abstract: | Objective To explore the feasibility and safety of Thalidomide and VAD scheme jointly treating multiple myeloma(MM).Methods Total 67 MM patients were randomly divided into the control group with 32 cases and the treatment group 35 cases:the control group used solely VAD chemotherapy scheme,the treatment group used Thalidomide on the basis of VAD scheme,starting dose 100mg/d,every evening meal or taking medicine in the morning or evening,increased 100mg every 2 weeks according to tolerated situations of pati... |
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| Keywords: | Multiple myeloma Thalidomide VAD Chemotherapy |
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