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| 改良保肾方Ⅱ号对大鼠糖尿病肾病的影响 | |
| 引用本文： | 张天星,耿建国,张胜容. 改良保肾方Ⅱ号对大鼠糖尿病肾病的影响[J]. 首都医科大学学报, 2008, 29(2): 178-180 |
| 作者姓名： | 张天星 耿建国 张胜容 |
| 作者单位： | 首都医科大学中医药学院中医临床基础教研室;首都医科大学附属北京中医医院肾病科 |
| 基金项目： | 首都医科大学校科研和教改项目 |
| 摘 要： | 目的探讨改良保肾方Ⅱ号对糖尿病肾病的影响及其作用机制。方法用链脲佐菌素(STZ)复制糖尿病肾病大鼠模型,观察改良保肾方Ⅱ号对其血糖、血脂、肾功能和肾脏形态学的影响。结果改良保肾方Ⅱ号组大鼠血糖、血脂、肾功指标均较模型组明显下降,差异有统计学意义(P<0.05),病理学改变也较模型组为轻。结论改良保肾方Ⅱ号能降低糖尿病肾病大鼠血糖和血脂,改善肾功能。 |
| 关 键 词： | 改良保肾方Ⅱ号 糖尿病肾病 肾功能 大鼠 |
| 收稿时间： | 2008-01-11 |
| 修稿时间： | 2008-01-11 |
Effects of Modified Baoshenfang No.2 on Diabetic Nephropathy in Rats |
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| Zhang Tianxing,Geng Jianguo,Zhang Shengrong. Effects of Modified Baoshenfang No.2 on Diabetic Nephropathy in Rats[J]. Journal of Capital Medical University, 2008, 29(2): 178-180 | |
| Authors: | Zhang Tianxing Geng Jianguo Zhang Shengrong |
| Affiliation: | 1. Department of Basic Clinical Traditional Chinese Medicine;School of Traditional Chinese Medicine;Capital Medical University;2. Department of Nephrology;Beijing Traditional Chinese Medicine Hospital;Capital Medical University |
| Abstract: | Objective To study the effect of modified Baoshenfang No.2 on diabetic nephropathy in rats. Methods The model of diabetic mellitus was established by intraperitoneal injection of sireptozotocin(STZ). Then, the levels of blood glucose and lipid as well as renal function(including serum creatinine, urine nitrogen, urine protein) were measured in each group of animals. At last, H-E staining was applied to observe changes in kidney morphology. Results Compared with the control group, intragastric administration... |
| Keywords: | modified Baoshenfang No.2 diabetic nephropathy renal function rats |
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