|
|||||
|
|
Production and characterisation of monoclonal antibodies against RAI3 and its expression in human breast cancer |
|
| Authors: | Hannah J?ri?en Nuran Bektas Edgar Dahl Arndt Hartmann Anette ten Haaf Stefano Di Fiore Hans Kiefer Andreas Thess Stefan Barth Torsten Klockenbring |
| Affiliation: | (1) Department of Pharmaceutical Product Development, Fraunhofer IME, Aachen, Germany;(2) Molecular Oncology Group, Institute of Pathology, University Hospital of the RWTH Aachen, Aachen, Germany;(3) Department of Pathology, University Hospital Erlangen, Erlangen, Germany;(4) Institute for Molecular Biotechnology, RWTH Aachen, Aachen, Germany;(5) M-fold Biotech, T?bingen, Germany;(6) CureVac GmbH, T?bingen, Germany;(7) Department for Experimental Medicine and Immunotherapy, University Hospital of the RWTH Aachen, Aachen, Germany |
| Abstract: | BackgroundRAI3 is an orphan G-protein coupled receptor (GPCR) that has been associated with malignancy and may play a role in the proliferation of breast cancer cells. Although its exact function in normal and malignant cells remains unclear and evidence supporting its role in oncogenesis is controversial, its abundant expression on the surface of cancer cells would make it an interesting target for the development of antibody-based therapeutics. To investigate the link with cancer and provide more evidence for its role, we carried out a systematic analysis of RAI3 expression in a large set of human breast cancer specimens. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |