基于羊水代谢组学策略评价妊娠禁忌中药的安全性

妊娠期用药的安全性是当前亟需解决的问题，羊水作为一种生物体液，能同时反映胎儿和母体的健康状况，被用作临床条件下有力的诊断学工具。该文总结了近年来羊水代谢组学在胎儿预测中的相关研究，并以课题组前期研究为例，讨论了羊水代谢组学应用于妊娠期中药安全性评价的优势与可行性。我们认为羊水代谢组学作为一种创新工具，具有更高的敏感性和相关性，在中药的毒性筛查及机制研究方面有广泛的应用前景。 

Evaluation of the Safety of Contraindicational Chinese Medicine in Pregnancy Based on the Strategy of Amniotic Fluid Metabolomics

Medication in pregnancy is inevitable， and the public urgently needs accurate toxicological data to evaluate the safety of traditional Chinese medicine. Amniotic fluid can reflect the health status of the fetus as well as the mother at the same time. The change of amniotic fluid metabolism pattern is related to the pathogenesis during pregnancy. In this paper， the related researches on amniotic fluid metabolomics in fetal prediction were summarized and we took an our previous study as an example to discuss the advantages and feasibility of amniotic fluid metabolomics in the safety evaluation of Chinese medicine during pregnancy. We believe that the metabolomics of amniotic fluid， as an innovative tool with higher sensitivity and relevance， will have broad application prospects in toxicity screening and mechanism research of Chinese medicine.