2016-2018年天津儿童医院含β2受体激动剂药品使用情况分析

目的了解天津市儿童医院含β2受体激动剂药品的使用情况,为临床药品管理和合理用药提供参考。方法收集天津市儿童医院2016-2018年门诊药房使用含β2受体激动剂药品的相关数据信息,统计药品相关指标,并分析其变化趋势。结果 2016-2018年含β2受体激动剂药品的用药金额及使用率呈现逐年递增趋势,尤其在2018年,口服用含β2受体激动剂药品的用药金额大幅增长,使用率明显增高。应用含β2受体激动剂药品的用药频度(DDDs)排序前3位的药品依次是盐酸丙卡特罗片、盐酸丙卡特罗口服液、布地奈德福莫特罗粉吸入剂(80μg∶4.5μg);日均费用(DDC)最高的是硫酸特布他林雾化溶液,口服药品中DDC最高的是氨溴特罗口服液。结论天津市儿童医院含β2受体激动剂药品的用药金额和使用率与儿童呼吸系统疾病季节性发病特点密切相关,临床应用基本合理,同时应及时了解临床用药现状,规范管理,合理用药。

Research advances in pharmacologic effects of matrine against HepG2 cells

Matrine inhibits proliferation, migration, invasion, and expression of vascular endothelial growth factor, and induces apoptosis and differentiation in association with dosage on human hepatoma HepG2 cells. Matrine is a inducer of early stage of autophagy, and is more a inhibitor of late stage of autophagy. Matrine has the effect against HepG2 cells by induction of mitochondria stress and endoplasmic reticulum stress, and inhibition of ERK pathway, expression of human cervical cancer oncogene-1 and Apollon gene, and telomerase activity.