胎盘生长因子和白细胞介素10水平与急性冠状动脉事件的相关性

目的通过对急性冠状动脉综合征患者血清胎盘生长因子和白细胞介素10水平的测定,探讨其在急性冠状动脉综合征的早期预测及预后判断中的价值。方法将90例患者分为ST段抬高型急性心肌梗死组(n=26)、非ST段抬高型急性心肌梗死/不稳定型心绞痛组(n=36)、稳定型心绞痛组(n=14)和对照组(n=14)。采用ELISA法检测各组血清胎盘生长因子和白细胞介素10水平;随访并观察各组30天、90天后主要心血管事件(死亡、再梗死和紧急血运重建)的发生。结果ST段抬高型急性心肌梗死患者和非ST段抬高型急性心肌梗死/不稳定型心绞痛患者血清胎盘生长因子水平较稳定型心绞痛患者明显升高,而白细胞介素10水平显著降低(P(0.01)。具有高水平血清胎盘生长因子的患者在随访30天及90天的心血管事件发生率明显增加,而具有高水平白细胞介素10的患者心血管事件发生率明显降低。相关性分析显示,血清胎盘生长因子与白细胞介素10水平呈负相关。结论血清胎盘生长因子可能是早期预测急性冠状动脉综合征的有力指标,血清胎盘生长因子与白细胞介素10两者之间的平衡,可能是预测急性冠状动脉综合征患者预后转归的重要因素。

The Relationship of Placenta Growth Factor and Interleukin-10 in the Risk for Cardiovascular Events of Acute Coronary Syndrome

Aim Through the confer of concentration of placenta growth factor(PLGF) and interleukin-10 (IL-10) to explore its early prediction and prognostic value in acute coronary syndrome (ACS) patients. Methods 90 patients were divided into experimental sub-STEMI group, NSTEMI/UAP group, SAP group and control group. The concentration of PLGF and IL-10 were measured by the method of enzyme linked immunosorbent assay (ELISA). The risk of follow-up cardiovascular events were detected during 30 days and 3 months, then the results were statisticly analyzed. Result The serum level of PLGF was higher in STEMI group and NSTEMI/UAP group than that of SAP group, but the concentration of IL-10 was lower in STEMI group and NSTEMI/UAP group than that of SAP group (P<0.01). The risk of cardiovascular events were increased in patients with higher serum level of PLGF, which was decreased in patients with higher serum level of IL-10 during 30 days and 3 months of follow-up. There was an inverse correlation between the serum level of PLGF and IL-10. Conclusions PLGF may be early indicators of ACS powerful, the balance between PLGF and IL-10 is a major determinant of outcome in patients with ACS.