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Cytotoxic and DNA damaging activity of some aporphine alkaloids from Stephania dinklagei
Authors:Gören Ahmet C  Zhou Bing-Nan  Kingston David G
Affiliation:Materials and Chemical Technologies Research Institute, TUBITAK, Marmara Research Center, PO Box 21, 41470 Gebze-Kocaeli, Turkey. ahmet.goren@ume.tubitak.gov.tr
Abstract:
Six aporphine alkaloids, liriodenine, corydine, isocorydine, atherospermidine, stephalagine and dehydrostephalagine, were isolated by bioassay-guided fractionation of the EtOH extract of the stems of Stephania dinklagei. Liriodenine showed strong cytotoxic activity while corydine and atherospermidine showed DNA damaging activity. Dehydrostephalagine and atherospermidine were isolated from this plant for the first time.
Keywords:
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