冠心病患者左冠脉血流和左室舒张功能与正常人对比分析

用经胸超声心动图（TTE）研究97例正常人和106例冠心病（CAD）患者的左冠状动脉主干（LMCA）血流和左室舒张功能（LVDF）。根据年龄分别分为三个年龄组。大多数受检者LMCA显示满意。与正常人相比，CAD患者LMCA的内径（D）粗细差异大，管腔内可见斑块（21例检测结果被冠脉造影证实），舒张期最大血流速度（Vmax）降低，每分钟血流量（Q）减少。评价LVDF是将脉冲多普勒取样容积置于二尖瓣（MV）前、后叶开放中点，通过测量二尖瓣下舒张早期充盈峰（E）和舒张晚期充盈峰（A）的Vmax和时间速度积分（TVI）及其比值来判断。正常人LVDF与年龄密切相关，随年龄的增加而降低。冠心病患者LVDF较相同年龄组正常人低，且年龄越大，差别越显著。

Detection of Peripheral Left Ventricular Diastolic Function of Patients with Coronary Artery Disease In Comparison with Normal Persons

The left ventricular diastolic function (LVDF) and left main coronary artery (LMCA) of 106 patients with coronary artery disease (CAD) and 97 normal subjects were studied by transthoracic two-dimensional color Doppler echocardiography (TTE). According to their ages, these two groups divided into three subgroups.The internal diameter of LMCA in the CAD patients differed in size and atherosclerotic plaques were found. LVDF was evaluated by left ventricular diastolic flow velocity waveforms recorded by pulsed wave technique and sample volume placed between the mitral leaflets. The measurements included the makimal velocity, time-velocity integral of the early filling, the atrial filling in diastole and their ratio. The higher the age, the lower the LVDF in the normal group. LVDF of the CAD patients was lower than the age-matched normal cases.