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| 肺舒胶囊对慢性阻塞性肺疾病大鼠肺基质金属蛋白酶-2表达的影响 | |
| 引用本文： | 钟红卫,余鸿,旦开蓉,陈滟,刘敦玉. 肺舒胶囊对慢性阻塞性肺疾病大鼠肺基质金属蛋白酶-2表达的影响[J]. 辽宁中医药大学学报, 2007, 9(5): 171-172 |
| 作者姓名： | 钟红卫 余鸿 旦开蓉 陈滟 刘敦玉 |
| 作者单位： | 1. 泸州医学院附属中医院,四川,泸州,646000 2. 泸州医学院组胚教研室,四川,泸州,646000 |
| 摘 要： | 目的:探讨肺舒胶囊对慢性阻塞性肺疾病(COPD)大鼠肺组织中基质金属蛋白酶-2(MMP-2)表达的影响.方法:将30只Wistar大鼠随机分为对照组、COPD模型组和肺舒胶囊治疗组各10只,取各组大鼠肺组织作MMP-2免疫组化染色,进行图像分析.结果:模型组大鼠肺组织MMP-2的光密度值较对照组增大(P＜0.05);而治疗组大鼠肺组织MMP-2的光密度值较模型组减小(P＜0.05).结论:肺舒胶囊可降低COPD大鼠肺组织中MMP-2的表达. |
| 关 键 词： | 肺舒胶囊 慢性阻塞性肺疾病 大鼠 肺组织 基质金属蛋白酶-2 |
| 文章编号： | 1673-842X（2007）05-0171-02 |
| 修稿时间： | 2007-04-05 |
Effect of Feishu Capsule on Expression of Matrix Metalloproteinase-2 in Pulmonary Tissue of Rats Following Chronic Obstructive Pulmonary Disease |
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| ZHONG Hong-wei,YU Hong,DAN Kai-rong,CHEN Yan,LIU Dun-yu. Effect of Feishu Capsule on Expression of Matrix Metalloproteinase-2 in Pulmonary Tissue of Rats Following Chronic Obstructive Pulmonary Disease[J]. Journal of Liaoning University of Traditional Chinese Medicine, 2007, 9(5): 171-172 | |
| Authors: | ZHONG Hong-wei YU Hong DAN Kai-rong CHEN Yan LIU Dun-yu |
| Affiliation: | 1.Emergency Department of No.2 Affiliated Hospital, Luzhou Medical College, Luzhou 646000, Sichuan, China; 2.Department of Histology and Embryology, Luzhou Medical College, Luzhou 646000, Sichuan, China |
| Abstract: | Objective:To study the effect of Feishu capsule on expression of matrix metalloproteinase-2 (MMP-2)in pulmonary tissue of rats following chronic obstructive pulmonary disease(COPD). Methods:Thirty Wistar rats were randomly divided into three groups:control group(CG),model group (MG)and treatment group(TG).The expression of MMP-2 in pulmonary tissue of rats was studied with immunohistochmistry,then the results were analyzed by image processing system.Result:The optical density of MMP-2 in MG was bigger than that of CG(P<0.05),and in TG,it was smaller than that of MG.Conclusion:Feishu capsule could decrease the expression of MMP-2 in pulmonary tissue of rats following COPD. |
| Keywords: | Feishu capsule chronic obstructive pulmonary disease rats pulmonary tissue matrix metalloproteinase-2 |
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