缰核刺激对黑质多巴胺能神经元伤害性反应的影响

本文采用细胞外记录方法探讨缰核与黑质在痛觉机制中的关系。结果表明单脉冲刺激外侧缰核(LHb),可抑制大多数黑质致密部(SNC)多巴胺能(DA)神经元的自发放电活动;同时,使这些神经元的痛抑制反应明显延长。鉴于大多数LHb 神经元能被外周伤害性刺激所兴奋,本文结果提示 LHb-SNC 投射纤维可能是伤害性信息传入 SNC 的中枢途径之一。

THE EFFECTS OF THE LATERAL HABENULA STIMULATION ON THE SPONTANEOUS DISCHARGES AND THE NOCICEPTIVE RESPONSES OF DOPAMINERGIC NEURONS FROM SUBSTANTIA NIGRA IN THE RAT

The relationship of lateral habenula(LHb)and substantia nigra in the pain mechanism was investigated by extracellular recording.Single shokstismulation of LHb inhibited the spontaneous discharges of dopa- minergic neurons in the substantia nigra,pars compacta(SNC),in the rat,most of which were also inhibited by peripheral nociceptive stim- ulations(PNS).LHb stimulation prolonged PNS-induced inhibition of dopaminergic neurons.Since the majority of LHb neurons were excited by PNS,our results strongly suggest that LHb-SNC projective fibers might be one of the pathways,through which the nociceptive informa- tion enters SNC.