| 姜黄素衍生物FM0807的溶解特性与稳定性影响因素考察 |
| |
| 引用本文： | 王晓露,许建华,邓艳平,黄秀旺,吴敏,郭晓丹,魏晓霞.姜黄素衍生物FM0807的溶解特性与稳定性影响因素考察[J].福建医科大学学报,2011,45(2):106-108. |
| |
| 作者姓名： | 王晓露 许建华 邓艳平 黄秀旺 吴敏 郭晓丹 魏晓霞 |
| |
| 作者单位： | 福建医科大学药学院,福州,350004 |
| |
| 基金项目： | 福建省科技重点项目，福建省产业技术开发项目 |
| |
| 摘 要： | 目的研究姜黄素（Cur）衍生物FM0807的溶解特性与稳定性影响因素,为后续药效学研究奠定基础。方法在高温、高湿、强光照射条件下进行影响因素试验;利用HPLC测定FM0807在不同pH值缓冲液中水解动力学、油/水分配系数以及在不同溶液中的溶解度。结果 FM0807在高湿环境下较稳定,高温条件下有少量降解,强光照射下不稳定;在0.1 mol/L盐酸溶液中极微溶,在pH 6.8磷酸盐缓冲液和去离子水中几乎不溶;在不同pH值缓冲液中较稳定;不同pH值条件下表观油/水分配系数的对数值多在1～2之间,亲脂性较亲水性高。结论 FM0807为不易溶解物质,稳定性优于母核Cur。
|
| 关 键 词： | 姜黄素 药物稳定性 水解作用 |
Factors Influencing the Solubility and Stability of Curcumin Derivative-FM0807 |
| |
| WANG Xiaolu,XU Jianhua,DENG Yanping,Huang Xiuwang,WU Min,GUO Xiaodan,WEI Xiaoxia.Factors Influencing the Solubility and Stability of Curcumin Derivative-FM0807[J].Journal of Fujian Medical University,2011,45(2):106-108. |
| |
| Authors: | WANG Xiaolu XU Jianhua DENG Yanping Huang Xiuwang WU Min GUO Xiaodan WEI Xiaoxia |
| |
| Institution: | WANG Xiaolu,XU Jianhua,DENG Yanping,Huang Xiuwang,WU Min,GUO Xiaodan,WEI Xiaoxia Department of Pharmacy,Fujian Medical University,Fuzhou 350004,China |
| |
| Abstract: | Objective To assay factors which affect the solubility and stability of FM0807,laying the foundation for researches of the pharmacodynamics for the follow-up study.Methods High Performance Liquid Chromatography(HPLC) are used to measure stability kinetics of FM0807 in solutions with different pH values,solubility,and oil/water partition coefficient.Results FM0807 was very stable in the environment of high humidity,and its degradation was undetectable until the tenth day under high temperature,and it is unst... |
| |
| Keywords: | Curcumin drug stability hydrolysis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
