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| 非小细胞肺癌组织ERCC1和RRM1表达及其临床预后的相关性研究 | |
| 引用本文： | 林肖鹰,陈小岩,陈志忠. 非小细胞肺癌组织ERCC1和RRM1表达及其临床预后的相关性研究[J]. 福建医科大学学报, 2011, 45(1): 10-14 |
| 作者姓名： | 林肖鹰 陈小岩 陈志忠 |
| 作者单位： | 林肖鹰,LIN Xiaoying(福建医科大学,省立临床医学院,福建省立医院,胸外科,福州,350001);陈小岩,陈志忠,CHEN Xiaoyan,CHEN Zhizhong(福建医科大学,省立临床医学院,福建省立医院,病理科,福州,350001) |
| 摘 要： | 目的 探讨DNA修复基因蛋白ERCC1和RRM1在非小细胞肺癌(NSLCL)中的表达与临床预后的关系.方法 采用免疫组织化学Envision法检测91例NSLCL组织中ERCC1和RRM1的表达.结果 在NSLCL组织中,ERCC1阳性表达率为45.05% (41/91),RRM1表达率为70.33%(64/91),与... |
| 关 键 词： | DNA修复 癌,非小细胞肺 肺肿瘤 核苷酸类 基因 预后 |
Expression of ERCC1 and RRM1 in Non-Small Cell Lung Cancer (NSCLC) and Clinical Prognosis |
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| LIN Xiaoying,CHEN Xiaoyan,CHEN Zhizhong. Expression of ERCC1 and RRM1 in Non-Small Cell Lung Cancer (NSCLC) and Clinical Prognosis[J]. Journal of Fujian Medical University, 2011, 45(1): 10-14 | |
| Authors: | LIN Xiaoying CHEN Xiaoyan CHEN Zhizhong |
| Affiliation: | LIN Xiaoying1,CHEN Xiaoyan2,CHEN Zhizhong2 1.Department of Thoracic Surgery,2.Department of Pathology,Fujian Provincial Hospital,Provincial Clinical College of Fujian Medical University,Fuzhou 350001,China |
| Abstract: | Objective To investigate the relationship between the expression of ERCC1 and RRM1 in non-small cell lung cancer(NSCLC) and clinical prognosis.Methods Expression levels of ERCC1 and RRM1 in 91 NSLCL cases were detected by the Envision method.Results The total positive expression rate for ERCC1 and RRM1 was 45.05%(41/91) and 70.33%(64/91),respectively,which was significantly higher than that in adjacent normal lung tissues(P<0.05).The expression and expression levels of ERCC1 and RRM1 were not correlated wit... |
| Keywords: | Carcinoma Non-Small-Cell Lung Lung Neoplasms Nucleotides Genes Prognosis |
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