Platelet-derived bio-products: Classification update,applications, concerns and new perspectives |
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| Affiliation: | 1. Platelet Research Lab, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain;2. Hospital Universitario Central de Asturias (HUCA), Laboratorio de Diagnóstico Clínico Hematología, Oviedo, Spain;3. Centro Comunitario de Sangre y Tejidos de Asturias, Oviedo, Spain;4. Cabueñes Hospital Universitario (CAHU), Servicio de Cirugía Ortopédica y Traumatología (COT), Gijón, Spain;5. International consultancy in blood components quality / safety and DDR strategies, London, UK;6. Dept. of Medicine, University of Oviedo, Spain;1. Saskatoon Cancer Centre, Division of Oncology, College of Medicine, University of Saskatchewan, Canada;2. Faculty of Medicine and Dentistry, University of Alberta, Canada;3. International Consultancy in Blood Components Quality/Safety Improvement, Audit/Inspection and DDR Strategies, London, UK;4. Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan;5. International PhD Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan;1. Department of Anatomy, Santosh Medical College, India;2. Department of Paedodontics & Preventive Dentistry, Santosh Dental College & Hospital, India;3. Section of Dentistry, Springer Nature, India;1. Instituto Universitario Fernández-Vega, Fundación de Investigación Oftalmológica, Universidad de Oviedo, Oviedo, España;2. Hospital Universitario Los Arcos del Mar Menor, Pozo Aledo, Murcia, España;1. Emilia Romagna Cord Blood Bank-Transfusion Service, S.Orsola-Malpighi Teaching Hospital, Bologna, Italy;2. Ophthalmology Unit, DIMES, Alma Mater Studiorum University of Bologna and S.Orsola-Malpighi Teaching Hospital, Bologna, Italy;3. RAMSES Laboratory, Department of Research & Innovation, Istituto Ortopedico Rizzoli, Bologna, Italy |
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| Abstract: | ![]()
Platelet derived bio-products in the form of platelet rich plasma, plasma rich in growth factors, or plasma-free platelet releasates, are being studied worldwide with the aim of proving their efficacy in tissue regeneration within many different clinical areas, such as traumatology, maxillofacial surgery, ophthalmology, dermatology and otorhinolaryngology, amongst others. The current lack of consensus in the preparation method and application form, or in the quality assessment of each bio-product, precludes adequate interpretation of the relevance of reported clinical outcomes, and, while many in clinicians are very positive about them, many are sceptic. Relevant aspects of these products are considered to propose a classification nomenclature which would aid a comprehensive comparison of clinical outcomes of bio-products of the same characteristics. Finally, the uses of platelet-derived bio-products in in vitro culture (for cell therapy purposes) as a substitute of animal-origin sera, and other future perspectives of applications of platelet-derived bio-products are discussed. |
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| Keywords: | Platelets Platelet Rich Plasma (PRP) Regenerative medicine Bio-product Clinical applications |
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