Electrogénèse cardiaque du rat surrénalectomisé, interprétation en fonction des variations de gradients ioniques et de perméabilités membranaires

Summary The adrenalectomy induces a 15–20 mV decrease in cardiac resting membrane potential; acute disturbances of ventricular action potential recorded with ultramicroelectrode technique are also observed.These electrical changes can be reported to variations of ionic concentrations in adrenalectomized rats. The calculated values of equilibrium potentials for K⁺, Na⁺ and Cl^– could explain the decline in resting potential, but some experiments show that modifications of the membrane permeabilities could be also involved in the depolarizing processes.The disturbances of action potential result from the low resting potential.This fundamental study might contribute to a better interpretation of heart failure in adrenal insufficiency.

Je remercie vivement M. le Professeur Gargouïl de ses conseils éclairés qui ont permis de mener à bien ce travail.