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Keratin‐18 and microRNA‐122 complement alanine aminotransferase as novel safety biomarkers for drug‐induced liver injury in two human cohorts
Authors:Petra Thulin  Gunnar Nordahl  Marcus Gry  Getnet Yimer  Eleni Aklillu  Eyasu Makonnen  Getachew Aderaye  Lars Lindquist  C. Mikael Mattsson  Björn Ekblom  Daniel J. Antoine  B. Kevin Park  Stig Linder  Alison H. Harrill  Paul B. Watkins  Björn Glinghammar  Ina Schuppe‐Koistinen
Affiliation:1. AstraZeneca R&D, Innovative Medicines Personalised Healthcare & Biomarkers, Science for Life Laboratory, , Solna, Sweden;2. Former AstraZeneca R&D, Global Safety Assessment, Molecular Toxicology, , S?dert?lje, Sweden;3. Department of Pharmacology, Faculty of Medicine, Addis Ababa University, , Addis Ababa, Ethiopia;4. Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, , Huddinge, Sweden;5. Department of Internal Medicine, Faculty of Medicine, Addis Ababa University, , Addis Ababa, Ethiopia;6. Department of Medicine, Division of Infectious Diseases, Karolinska Institutet, Karolinska University Hospital, , Huddinge, Sweden;7. ?strand Laboratory of Work Physiology, Swedish School of Sport and Health Sciences, Karolinska Institutet, , Stockholm, Sweden;8. MRC Centre for Drug Safety Science, Department of Molecular & Clinical Pharmacology, University of Liverpool, , Liverpool, UK;9. Department of Oncology‐Pathology, Karolinska Institutet, Karolinska University Hospital, , Solna, Sweden;10. School of Pharmacy, University of North Carolina at Chapel Hill, , Chapel Hill, NC, USA;11. AstraZeneca R&D, Drug Safety & Metabolism, , M?lndal, Sweden
Abstract:
Keywords:acetaminophen  biomarkers  drug development  hepatotoxicity     HIV     liver  plasma  safety  toxicology  tuberculosis
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