Cytokine profile in the gingival crevicular fluid of rheumatoid arthritis patients with chronic periodontitis |
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| Authors: | Fawad Javed Hameeda B. Ahmed Toshinari Mikami Khalid Almas Georgios E. Romanos Khalid Al‐Hezaimi |
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| Affiliation: | 1. Engineer Abdullah Bugshan Research Chair for Growth Factors and Bone Regeneration, 3D Imaging and Biomechanical Laboratory, College of Applied Medical Sciences, King Saud University, , Riyadh, Saudi Arabia;2. Department of Dentistry, Al‐Farabi Dental College, , Riyadh, Saudi Arabia;3. Division of Anatomical and Cellular Pathology, Department of Pathology, Iwate Medical University, , Iwate, Japan;4. Division of Periodontology, School of Dentistry, University of Connecticut, , Farmington, CT, USA;5. Department of Dental Medicine, School of Dental Medicine, Stony Brook University, , Stony Brook, NY, USA;6. Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, , Riyadh, Saudi Arabia |
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| Abstract: | The aim was to assess the cytokine profile in the gingival crevicular fluid (GCF) of rheumatoid arthritis (RA) patients with chronic periodontitis (CP). Databases were searched from 1991 to August 2013 using a combination of various keywords. Eight studies were included. The GCF concentrations of interleukin (IL)‐1β, IL‐4, IL‐10, matrix metalloproteinase (MMP)‐8, MMP‐13 and tumor necrosis factor‐alpha (TNF‐α) were reported to be higher in patients with RA than in healthy controls (HC) without CP. In one study, TNF‐α levels in GCF were significantly higher in HC than in RA patients receiving anti‐TNF‐α therapy. One study reported no significant difference in GCF TNF‐α levels among RA patients and HC regardless of anti‐TNF‐α therapy. One study reported no difference in IL‐1β and prostaglandin E2 levels among RA patients and HC with CP. Raised levels of proinflammatory cytokines are exhibited in the GCF of RA patients with CP. |
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| Keywords: | chronic periodontitis cytokine gingival crevicular fluid rheumatoid arthritis |
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