|
|||||
|
|
Paracoccidioidomycosis in Mexico: clinical and epidemiological data from 93 new cases (1972–2012) |
|
| Authors: | Rubén López‐Martínez Francisca Hernández‐Hernández Luis Javier Méndez‐Tovar Patricia Manzano–Gayosso Alexandro Bonifaz Roberto Arenas María del Carmen Padilla‐Desgarennes Roberto Estrada Guadalupe Chávez |
| Affiliation: | 1. Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, , México, D. F., México;2. Laboratorio de Investigación Médica en Dermatología y Micología, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, , México, D. F., México;3. Departamento de Micología, Servicio de Dermatología, Hospital General de México “Dr. Eduardo Liceaga”, , México, D. F., México;4. Servicio de Dermatología y Micología, Hospital General “Manuel Gea González”, Secretaría de Salud, , México, D. F., México;5. Laboratorio de Micología, Centro Dermatológico “Ladislao de la Pascua”, Secretaría de Salud, , México, D. F., México;6. Facultad de Medicina, Universidad Autónoma de Guerrero, , Acapulco, México |
| Abstract: | Paracoccidioidomycosis (PCM) is an endemic systemic infection in several countries of Latin America. The few registered cases in Mexico most likely do not reflect the real frequency. Disseminate the epidemiological and clinical data of unreported cases of PCM in Mexico from 1972 until 2012 is the aim of this work. Epidemiological and clinical information of non‐published cases of PCM was requested from the principal mycological diagnosis centres in Mexico. A total of 93 cases were received. The infection was found predominantly in men (95.7%), peasants (88.5%) and individual between 31 and 60 years of age. Most of the cases were found in tropical areas of the Gulf of Mexico (54.84%) and the Pacific littoral (20.3%). The main sites of dissemination were the oral mucosa (39.38%) and skin (34.05%). The most effective treatments were itraconazole alone and the combination of itraconazole with sulfamethoxazole‐trimethoprim. PCM is a subdiagnosed pathology in Mexico. Therefore, adequate training is necessary to determine the current status of this mycosis. |
| Keywords: | Paracoccidioidomycosis Paracoccidioides brasiliensis systemic mycosis |