| DHAQ抗癌作用的实验研究 |
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| 引用本文： | 王朝俊,刘瑜玲,李玉琼,罗德元,胥佩菱,肖素华,廖永芳,何菱. DHAQ抗癌作用的实验研究[J]. 四川大学学报(医学版), 1987, 0(3) |
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| 作者姓名： | 王朝俊 刘瑜玲 李玉琼 罗德元 胥佩菱 肖素华 廖永芳 何菱 |
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| 作者单位： | 华西医大肿瘤研究所(王朝俊，刘瑜玲，李玉琼，罗德元)，华西医大药学院有机化学教研室(胥佩菱，肖素华，廖永芳)，华西医大药学院有机化学教研室(何菱) |
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| 摘 要： | 作者用自行合成的DHAQ,经几种常用的动物实验系统瘤株进行抗癌检测,结果表明:本品有明显的抗癌抑癌作用,其效果与国外同样药物的抗癌活性相似。说明该药是一种值得深入研究的新抗癌药物。
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| 关 键 词： | DHAQ 抗癌作用 瘤株 实验动物 |
STUDIES ON ANTITUMOR ACTIVITY OF MITOXANTRONE IN ANIMALS |
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| Wang Chaojun,Liu Yuling,Li Yuqiong,Luo Deyuan Institute of Cancer Research Xu Peiling,Xiao Suhua,Liao Yongfang,He Ling. STUDIES ON ANTITUMOR ACTIVITY OF MITOXANTRONE IN ANIMALS[J]. Journal of Sichuan University. Medical science edition, 1987, 0(3) |
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| Authors: | Wang Chaojun Liu Yuling Li Yuqiong Luo Deyuan Institute of Cancer Research Xu Peiling Xiao Suhua Liao Yongfang He Ling |
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| Affiliation: | Wang Chaojun,Liu Yuling,Li Yuqiong,Luo Deyuan Institute of Cancer Research Xu Peiling,Xiao Suhua,Liao Yongfang,He Ling Department of Organic Chemistry,School of Pharmacy |
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| Abstract: | DHAQ (Mitoxantrone; 1, 4-Dihydroxy-5, 8-bis [[2- (2-hydroxyethyl)-aminoethyl]amino]-9, 10-anthracenedione) was synthe-sized into a five-step sequence from theoriginal chemicals. Studies on its antitumoractivity were made in animal test systems.The Ehrlich ascitic carcinoma, cervical car-cinoma U27, sarcoma-180 and leukemiaP388 were used. The results revealed thatDHAQ had a significant activity againsttumors in a few animal experimentalsystems. In water DHAQ lost its activityeasily, so further study should be made tochoose an approprlate solvent, a properstabllizer and its dosage. |
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| Keywords: | Mitoxantrone(DHAQ) Antitumor activity Experiment animal Tumor strain |
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