米非司酮治疗子宫腺肌症疗效评价

目的:探讨小剂量米非司酮治疗子宫腺肌症的临床疗效及其安全性。方法:对2004年6月~2008年5月在我院就诊的子宫腺肌症患者中,要求药物治疗的58例作为研究对象,所有患者全部口服米非司酮治疗,观察闭经时间、痛经症状改善情况、子宫体积及内膜的变化、激素水平变化和不良反应。结果:服药期间所有患者均闭经,痛经消失8例(13.8%),50例痛经减轻(86.2%),子宫体积由治疗前的(89.35±10.32)cm3缩小至(58.56±9.07)cm3,子宫内膜变薄,由治疗前的(9.26±1.3)cm减少为(5.29±0.58)cm。58例患者中,仅10例出现轻微胃肠道反应,3例转氨酶轻度升高,余无明显不良反应。结论:小剂量米非司酮治疗子宫腺肌症有效、安全、经济。

Evaluation treatment of mifepristone in adenomyosis

Objective: Discusses the effect of adenomyosis treated by small dose mifepristone.Methods:58 example uterine gland muscle sickness patient who treated by mifepristone in my hospital during June.2004~May.2008,the observation menopause time,the painful menstruation symptom improvement change of situation,the womb volume and internal membrane,the hormone level change and the untoward effect.Results:Taking medicine period all patients stop menstruating,the painful menstruation vanishes 8 examples(13.8%),50 example painful menstruations reduce(86.2%),the womb volume before treatment(89.35±10.32) cm3 reduction to(58.56±9.07) cm3,the endometrium thins,before the treatment(9.26±1.3) cm is reduation is(5.29±0.58) cm in 58 example patients,the only 10 examples present the slight gastro-intestinal tract to respond that 3 example transaminases elevate mildly,obvious untoward effect.Conclusion: The effect of adenomyosis treated by small dose mifepristone was to be effective,to be safe and to be economical.