喉癌颈部淋巴结微转移与早期复发及预后关系探讨

目的分析pN0喉鳞状细胞癌患者颈部淋巴结微转移与早期复发和预后的相关性。方法收集本院2005年7月～2009年4月诊治的喉鳞状细胞癌患者中行颈廓清术后经常规病理学HE染色切片检查pN0癌病例31例的临床及病理资料;石蜡包埋的颈廓清术淋巴结标本行半连续切片HE染色,经多名有经验的病理科医师重新阅片,证实有无微转移灶。采用χ2检验分析微转移与早期复发的相关性,Kaplan-Meier曲线用于描述有无微转移两组患者的无瘤生存(disease-free survival)曲线分布。结果全部31例418枚淋巴结蜡块标本中发现微转移8例,除年龄、分化程度外的各临床病理因素与微转移之间均无相关性,微转移与早期复发之间无相关性(P>0.05)。Kaplan-Meier曲线用于描述有、无微转移两组患者的无瘤生存(disease-free survival)曲线分布,两组患者的无瘤生存率无明显分离趋势(P>0.05)。结论本研究表明pN0喉鳞型细胞癌患者中,颈淋巴结中微转移灶的存在与复发和预后无关。

Relationship between micrometastasis in cervical lymph node and early recurrence and prognosis in patients with laryngocarcinoma of pN0 stage

Objective To analysis the correlation between micrometastasis in cervical lymph node and early recurrence,and prognosis in patients with laryngocarcinoma of pN0 stage.Methods The clinical and pathological data of 31 patients suffering from laryngeal squamous cell carcinoma with pathologically negative node were analyzed retrospectively.The micrometastasis was detected with HE staining combined with semi-consecutive sectioning from the lymph node specimens after neck dissection operation.The chi-square test was used for analyzing the relationship between the micrometastasis and early recurrence,and Kaplan-Meier curve was used for describing the disease-free survival curve.Results The correlation between micrometastasis and early recurrence was not significant(P>0.05).The disease-free survival rate of the patients with and without micrometastasis had no obvious separation trend(P>0.05).Conclusion In patients with laryngocarcinoma of pN0 stage,the clinical and prognostic implications of micrometastasis could not be established.