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Impact of AV Conduction Disorders on SafeR Mode Performance |
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| Authors: | BERNARD THIBAULT,M.D.,CHRISTOPHER SIMPSON,M.D.,&dagger ,CARL-É RIC GAGNÉ ,M.D.,&Dagger ,LOUIS BLIER,M.D.,§ ,MANOHARA SENARATNE,M.D.,¶ SERGE McNICOLL,M.D.,CARLO STUGLIN,M.D.,&dagger &dagger ,RANDY WILLIAMS,M.D.,&Dagger &Dagger ,ARNOLD PINTER,M.D.,§ § ,YAARIV KHAYKIN,M.D.,¶ ¶ , REMI NITZSCHE,M.S. |
| Affiliation: | From the Montreal Heart Institute, Montreal, Quebec, Canada;;Kingston General Hospital, Kingston, Ontario, Canada;;Centre Hospitalier Regional, Trois-Rivieres, Quebec, Canada;;Hôpital Laval, Quebec, Quebec, Canada;;Grey Nuns Community Hospital, Edmonton, Alberta, Canada;;Hotel Dieu de Saint Jerome, Quebec, Canada;;Royal University Hospital, Saskatoon, Saskatchewan, Canada;;Royal Alexandra Hospital, Edmonton, Alberta, Canada;;St. Michael's Hospital, Toronto, Ontario, Canada;;Southlake Regional Health Centre, Newmarket, Ontario, Canada;;and Sorin Group, Markham, Ontario, Canada |
| Abstract: | Purpose: CAN-SAVE R is a Canadian multicenter study that compares the effects of a new pacing mode algorithm designed to minimize right ventricular (V) pacing versus DDD mode with a long atrioventricular (AV) delay in a general population of pacemaker (PM) recipients . Study Participants: Patients with permanent atrial fibrillation (AF) or high-degree AV block (AVB) were excluded. We present preliminary data collected in 208 patients (mean age = 71 ± 11 years, 68% men), for the 2-month baseline period during which all PM were programmed in the new pacing mode. The pacing indications were sinus node disease (SND) without AVB in 39%, AVB without SND in 30%, SND and AVB in 16%, and miscellaneous in 15% of patients. Results: The mean percent V pacing in the overall population was 9.5 ± 23.8% (range = 0–100%, median <1%), ranging between 0.5 ± 1.5% (median = 0) in patients without AVB and 18.7 ± 31.2% in patients (median = 1) with AVB. Adverse events potentially related to the new pacing mode were observed in two patients with AVB. Conclusions: A new pacing mode was effective and safe in a general population of PM recipients without permanent AVB and was associated with an overall <1% median V pacing. CAN-SAVE R will compare the long-term effects of the new pacing mode with DDD with a long AV delay on clinical outcomes and cardiac function. |
| Keywords: | atrial pacing ventricular pacing dual-chamber pacing automatic mode switch sinus node dysfunction atrioventricular block |